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| - | ==Human CD81 Large extracellular loop P31 crystal form==
| + | REMOVED: The PDB entry 4bto was removed. |
| - | <StructureSection load='4bto' size='340' side='right' caption='[[4bto]], [[Resolution|resolution]] 2.40Å' scene=''>
| + | |
| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4bto]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BTO FirstGlance]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene><br>
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| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4btn|4btn]]</td></tr>
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| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bto RCSB], [http://www.ebi.ac.uk/pdbsum/4bto PDBsum]</span></td></tr>
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| - | <table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Abrescia, N G.]]
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| - | [[Category: Cunha, E S.]]
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| - | [[Category: Ondiviela, M.]]
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| - | [[Category: Roversi, P.]]
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| - | [[Category: Wojtas, M N.]]
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| - | [[Category: Hcv]]
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| - | [[Category: Immune system]]
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| - | [[Category: Receptor]]
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