4qpn

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==Crystal Structure of Human Methyltransferase-Like Protein 21B==
==Crystal Structure of Human Methyltransferase-Like Protein 21B==
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<StructureSection load='4qpn' size='340' side='right' caption='[[4qpn]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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<StructureSection load='4qpn' size='340' side='right'caption='[[4qpn]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qpn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QPN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qpn RCSB], [http://www.ebi.ac.uk/pdbsum/4qpn PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpn OCA], [https://pdbe.org/4qpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpn RCSB], [https://www.ebi.ac.uk/pdbsum/4qpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EFMT3_HUMAN EFMT3_HUMAN] Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.<ref>PMID:28108655</ref> <ref>PMID:28663172</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H.]]
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[[Category: Homo sapiens]]
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[[Category: Brown, P J.]]
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[[Category: Large Structures]]
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[[Category: Edwards, A M.]]
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[[Category: Arrowsmith CH]]
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[[Category: Graslund, S.]]
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[[Category: Brown PJ]]
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[[Category: He, H.]]
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[[Category: Edwards AM]]
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[[Category: Hong, B S.]]
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[[Category: Graslund S]]
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[[Category: Li, Y.]]
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[[Category: He H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Hong BS]]
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[[Category: Seitova, A.]]
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[[Category: Li Y]]
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[[Category: Tempel, W.]]
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[[Category: Seitova A]]
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[[Category: Sgc]]
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[[Category: Tempel W]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Human Methyltransferase-Like Protein 21B

PDB ID 4qpn

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