4fqk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (02:53, 21 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex==
==Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex==
-
<StructureSection load='4fqk' size='340' side='right' caption='[[4fqk]], [[Resolution|resolution]] 5.65&Aring;' scene=''>
+
<StructureSection load='4fqk' size='340' side='right'caption='[[4fqk]], [[Resolution|resolution]] 5.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4fqk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4fqk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Brisbane/60/2008) Influenza B virus (B/Brisbane/60/2008)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQK FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.65&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fnk|4fnk]], [[4fqh|4fqh]], [[4fqi|4fqi]], [[4fqj|4fqj]], [[4fql|4fql]], [[4fqm|4fqm]], [[4fqv|4fqv]], [[4fqy|4fqy]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11520 Influenza B virus])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqk OCA], [https://pdbe.org/4fqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqk RCSB], [https://www.ebi.ac.uk/pdbsum/4fqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqk ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fqk RCSB], [http://www.ebi.ac.uk/pdbsum/4fqk PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/C0LT38_9INFB C0LT38_9INFB] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4fqk" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Antibody|Antibody]]
+
*[[Antibody 3D structures|Antibody 3D structures]]
-
*[[Hemagglutinin|Hemagglutinin]]
+
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 +
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
Line 25: Line 29:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Influenza b virus]]
+
[[Category: Large Structures]]
-
[[Category: Dreyfus, C.]]
+
[[Category: Dreyfus C]]
-
[[Category: Laursen, N S.]]
+
[[Category: Laursen NS]]
-
[[Category: Wilson, I A.]]
+
[[Category: Wilson IA]]
-
[[Category: Antibody]]
+
-
[[Category: Fab fragment]]
+
-
[[Category: Immunoglobulin]]
+
-
[[Category: Monoclonal]]
+
-
[[Category: Viral protein-immune system complex]]
+

Current revision

Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex

PDB ID 4fqk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fqk"
Personal tools