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4fql

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==Influenza B HA Antibody (Fab) CR8033==
==Influenza B HA Antibody (Fab) CR8033==
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<StructureSection load='4fql' size='340' side='right' caption='[[4fql]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4fql' size='340' side='right'caption='[[4fql]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fql]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQL FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fnk|4fnk]], [[4fqh|4fqh]], [[4fqi|4fqi]], [[4fqj|4fqj]], [[4fqk|4fqk]], [[4fqm|4fqm]], [[4fqv|4fqv]], [[4fqy|4fqy]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.898&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fql RCSB], [http://www.ebi.ac.uk/pdbsum/4fql PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fql OCA], [https://pdbe.org/4fql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fql RCSB], [https://www.ebi.ac.uk/pdbsum/4fql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fql ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a significant part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.
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Highly Conserved Protective Epitopes on Influenza B Viruses.,Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin O, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH Science. 2012 Aug 9. PMID:22878502<ref>PMID:22878502</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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*[[3D structures of human antibody|3D structures of human antibody]]
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dreyfus, C.]]
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[[Category: Large Structures]]
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[[Category: Laursen, N S.]]
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[[Category: Dreyfus C]]
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[[Category: Wilson, I A.]]
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[[Category: Laursen NS]]
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[[Category: Fab fragment]]
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[[Category: Wilson IA]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Influenza b virus]]
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[[Category: Monoclonal]]
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[[Category: Viral]]
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Current revision

Influenza B HA Antibody (Fab) CR8033

PDB ID 4fql

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