Human rhinovirus

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== Function ==
== Function ==
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'''Human rhinovirus''' (HRV) are RNA viruses. The HRV capsid is composed of 4 proteins: VP1, VP2, VP3 and VP4. The capsid structure is that of a icosahedron with 60 copies of each of its viral proteins.
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'''Human rhinovirus''' (HRV) are RNA viruses. The HRV capsid is composed of 4 proteins: VP1, VP2, VP3 and VP4. The capsid structure is that of a icosahedron with 60 copies of each of its viral proteins<ref>PMID:7915182</ref><ref>PMID:23297263</ref>.
== Disease ==
== Disease ==
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HRV are responsible for the majority of cold-like illnesses.
HRV are responsible for the majority of cold-like illnesses.
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== Relevance ==
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</StructureSection>
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== Structural highlights ==
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==3D structures of human rhinovirus==
==3D structures of human rhinovirus==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Human rhinovirus 1A
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**[[1r1a]] – HRV1A VP1+VP2+VP3+VP4 <br />
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**[[2hwd]], [[2hwe]], [[2hwf]] – HRV1A VP1+VP2+VP3+VP4 + antiviral agent<br />
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*Human rhinovirus 2
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**[[1fpn]] – HRV2 VP1+VP2+VP3+VP4 <br />
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**[[8ay4]], [[8ay5]] – HRV2 VP1+VP2+VP3+VP4 – Cryo EM<br />
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**[[1v9u]], [[3dpr]] – HRV2 VP1+VP2+VP3+VP4 + LDL-receptor class A3<br />
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**[[3vdd]] – HRV2 VP1+VP2+VP3+VP4 + antiviral agent<br />
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*Human rhinovirus B5
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**[[6sk6]] – HRVB5 VP1+VP2+VP3+VP4 – Cryo EM<br />
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**[[6sk5]] – HRVB5 VP1+VP2+VP3+VP4 + antiviral agent – Cryo EM<br />
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*Human rhinovirus 2A
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**[[2m5t]] – HRV2A proteinase - NMR <br />
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**[[7ara]] – HRV2A proteinase + inhibitor<br />
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*Human rhinovirus 3
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**[[1rhi]] – HRV3 VP1+VP2+VP3+VP4 <br />
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*Human rhinovirus 3C
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**[[2xya]], [[6sk7]] – HRV3C proteinase <br />
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**[[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]], [[6ku8]] – HRV3C proteinase + inhibitor<br />
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*Human rhinovirus 14
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**[[4rhv]], [[1rmu]] – HRV14 VP1+VP2+VP3+VP4 <br />
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**[[1r08]], [[2r04]], [[2r06]], [[2r07]], [[2rm2]], [[2rmu]], [[2rr1]], [[2rs1]], [[2rs3]], [[2rs5]], [[1r09]], [[1hri]], [[2hwb]], [[2hwc]], [[1hrv]], [[1na1]], [[1ncq]] – HRV14 VP1+VP2+VP3+VP4 + antiviral agent<br />
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**[[1ruc]], [[1rud]], [[1rue]], [[1ruf]], [[1rug]], [[1ruh]], [[1rui]], [[1ruj]], [[1vrh]] – HRV14 VP1+VP2+VP3+VP4 (mutant) + antiviral agent<br />
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**[[1rvf]] – HRV14 VP1+VP2+VP3+VP4 + antibody<br />
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**[[1d3i]] – HRV14 VP1+VP2+VP3+VP4 + intercellular adhesion molecule – Cryo-EM<br />
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**[[1k5m]] – HRV14 VP1+VP2/V3 of Gp120+VP3+VP4 <br />
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**[[6kyz]], [[6kz0]] – HRV14 3C + antibody <br />
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**[[6hlt]] – HRV14 + GCP60 <br />
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**[[7nul]], [[7num]], [[7nuo]] – HRV14 polyprotein – Cryo-EM<br />
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**[[7nun]], [[7nuq]] – HRV14 polyprotein + polynucleotide – Cryo-EM<br />
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**[[7bg6]] – HRV14 polyprotein + RNA – Cryo-EM<br />
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**[[7bg7]] – HRV14 polyprotein + ICAM-1 – Cryo-EM<br />
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*Human rhinovirus C15
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**[[6ppo]], [[6psf]] – HRVC15 VP1+VP2+VP3+VP4 + CDHR3 – Cryo EM<br />
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**[[5x45]] – HRVC15 847-983<br />
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===Human rhinovirus 14===
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*Human rhinovirus C
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[[4rhv]], [[1rmu]] – HRV14 VP1+VP2+VP3+VP4 <br />
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**[[5jzg]] – HRVC VP1 (mutant) +VP3+VP0 – Cryo EM<br />
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[[1r08]], [[2r04]], [[2r06]], [[2r07]], [[2rm2]], [[2rmu]], [[2rr1]], [[2rs1]], [[2rs3]], [[2rs5]], [[1r09]], [[1hri]], [[2hwb]], [[2hwc]], [[1hrv]], [[1na1]], [[1ncq]] – HRV14 VP1+VP2+VP3+VP4 + antiviral agent<br />
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**[[5k0u]] – HRVC VP1 (mutant) + VP2 +VP3+VP4 – Cryo EM<br />
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[[1ruc]], [[1rud]], [[1rue]], [[1ruf]], [[1rug]], [[1ruh]], [[1rui]], [[1ruj]], [[1vrh]] – HRV14 VP1+VP2+VP3+VP4 (mutant) + antiviral agent<br />
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[[1rvf]] – HRV14 VP1+VP2+VP3+VP4 + antibody<br />
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[[1d3i]] – HRV14 VP1+VP2+VP3+VP4 + intercellular adhesion molecule – Cryo-EM<br />
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[[1k5m]] – HRV14 VP1+VP2/V3 of Gp120+VP3+VP4 <br />
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===Human rhinovirus 2===
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*Human rhinovirus 16
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[[1fpn]] – HRV2 VP1+VP2+VP3+VP4 <br />
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**[[1aym]], [[1ayn]], [[1c8m]] – HRV16 VP1+VP2+VP3+VP4 (mutant)<br />
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[[1v9u]], [[3dpr]] – HRV2 VP1+VP2+VP3+VP4 + LDL-receptor class A3<br />
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**[[1qju]], [[1qjx]], [[1qjy]] - HRV16 VP1+VP2+VP3+VP4 + antiviral agent<br />
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[[3vdd]] – HRV2 VP1+VP2+VP3+VP4 + antiviral agent<br />
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**[[1d3e]] – HRV16 VP1+VP2+VP3+VP4 + intercellular adhesion molecule – Cryo EM<br />
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}}
== References ==
== References ==

Current revision

Structure of human rhinovirus 14 viral proteins VP1 (sea green), VP2 (blue), VP3 (olive), VP4 (green) (PDB code 4rhv).

Drag the structure with the mouse to rotate

3D structures of human rhinovirus

Updated on 14-September-2025

References

  1. ↑ Oliveira MA, Zhao R, Lee WM, Kremer MJ, Minor I, Rueckert RR, Diana GD, Pevear DC, Dutko FJ, McKinlay MA, et al.. The structure of human rhinovirus 16. Structure. 1993 Sep 15;1(1):51-68. PMID:7915182
  2. ↑ Jacobs SE, Lamson DM, St George K, Walsh TJ. Human rhinoviruses. Clin Microbiol Rev. 2013 Jan;26(1):135-62. doi: 10.1128/CMR.00077-12. PMID:23297263 doi:http://dx.doi.org/10.1128/CMR.00077-12

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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