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NADPH dehydrogenase

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(New page: <StructureSection load='1oyb' size='340' side='right' caption='Structure of yeast NADPH dehydrogenase complex with FMN and p-hydroxybenzaldehyde (PDB code 1oyb).' scene=''> == Functi...)
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<StructureSection load='1k03' size='350' side='right' caption='Structure of yeast NADPH dehydrogenase complex with FMN, p-hydroxybenzaldehyde and Mg+2 ion (green) (PDB code [[1k03]]).' scene='59/595221/Cv/1'>
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<StructureSection load='1oyb' size='340' side='right' caption='Structure of yeast NADPH dehydrogenase complex with FMN and p-hydroxybenzaldehyde (PDB code [[1oyb]]).' scene=''>
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== Function ==
== Function ==
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'''NADPH dehydrogenase''' or '''old yellow enzyme''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN.
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'''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. '''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres.
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</StructureSection>
== 3D Structures of NADPH dehydrogenase ==
== 3D Structures of NADPH dehydrogenase ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*NADPH dehydrogenase
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**[[7blf]] – OYE + FMN - fungus<br />
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**[[1oyc]], [[1oya]] – yOYE + FMN - yeast<br />
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**[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br />
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**[[3tjl]] – SsOYE + FMN + malonate - ''Scheffersomyces stipitis'' <br />
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**[[6s32]] – OYE + FMN + benzamidine – ''Chroococcidiopsis thermalis''<br />
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**[[6s31]] – GsOYE + FMN + benzaldehyde – ''Galdieria sulphuraria''<br />
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**[[6s0g]], [[6s23]] – GsOYE + FMN <br />
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**[[6agz]] – OYE + FMN - ''Pichia''<br />
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**[[3kru]], [[3krz]] – OYE + FMN – ''Thermoanaerobacter pseudethanolicus''<br />
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**[[3atz]] – TcOYE + FMN + benzaldehyde – ''Trypanosoma cruzi''<br />
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**[[3aty]] – TcOYE + FMN <br />
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**[[2gou]], [[2gqa]] – SoOYE + FMN – ''Shewanella oneidensis''<br />
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**[[2gq9]] – SoOYE + FMN + benzaldehyde <br />
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**[[7o0t]] – OYE + FMN – ''Chloroflexus aggregans''<br />
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**[[3hgj]] – TsOYE + FMN + benzaldehyde – ''Thermus scotoductus''<br />
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**[[3hf3]] – TsOYE + FMN <br />
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*NADPH dehydrogenase 1
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**[[4rnu]], [[4rnw]], [[4rnx]] – yOYE 1 + FMN <br />
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**[[1k02]], [[4h6k]], [[4k7y]] – yOYE 1 (mutant) + FMN <br />
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**[[1bwk]], [[1bwl]] – OYE 1 (mutant) + FMN - ''Candida albicans''<br />
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**[[3gr7]], [[3gr8]] – OYE + FMN – ''Geobacillus kaustophilus''<br />
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**[[4rnv]], [[5v4p]] – yOYE 1 + FMN + p-hydroxybenzaldehyde <br />
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**[[1k03]] – yOYE 1 (mutant) + FMN + p-hydroxybenzaldehyde <br />
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**[[3rnd]] – yOYE 1 mutant) + FMN + hydroxymethyl cyclopent-2-en-one <br />
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**[[4yil]], [[4ync]] – yOYE 1 (mutant) + FMN + acrylate derivative <br />
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**[[4gbu]], [[4gxm]] – yOYE 1 (mutant) + FMN + methyl propenyl phenol <br />
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**[[4ge8]], [[3txz]], [[4gwe]], [[4h4i]], [[4k7v]], [[4k8e]], [[4k8h]] – yOYE 1 (mutant) + FMN + carvone <br />
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**[[3tx9]] – yOYE 1 + FMN + hydroxymethyl cyclopent-2-en-one <br />
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*NADPH dehydrogenase 2.6
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**[[4qai]] – SsOYE 2.6 (mutant) + FMN <br />
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**[[4m5p]] – SsOYE 2.6 + FMN + malonate <br />
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**[[3upw]] – SsOYE 2.6 + FMN + malonate + nicotineamide<br />
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**[[4df2]] – SsOYE 2.6 + FMN + malonate + chlorophenol<br />
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*NADPH dehydrogenase 3
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**[[5v4p]] – yOYE 3 + FMN + p-hydroxybenzaldehyde <br />
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**[[5v4v]] – yOYE 3 + FMN + nicotinamide <br />
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*NADPH dehydrogenase 4
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[[1oyc]], [[1oya]] – yOYE + FMN - yeast<br />
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**[[4b5n]] – SoOYE 4 + FMN <br />
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[[1k02]], [[4h6k]], [[4k7y]] – yOYE (mutant) + FMN <br />
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[[1bwk]], [[1bwl]] – OYE (mutant) + FMN - ''Candida albicans''<br />
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===NADPH dehydrogenase complexes===
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*NADPH dehydrogenase quinone 1
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[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br />
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**[[5a4k]] – hNQO1 (mutant) + FAD - human <br />
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[[1k03]] – yOYE (mutant) + FMN + p-hydroxybenzaldehyde <br />
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**[[5fuq]], [[4cet]] – hNQO1 (mutant) + FAD + dicoumarol <br />
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[[3rnd]] – yOYE (mutant) + FMN + hydroxymethyl cyclopent-2-en-one <br />
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**[[4cf6]] – hNQO1 (mutant) + FAD + cibacron blue <br />
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[[4gbu]], [[4gxm]], [[4k8e]] – yOYE (mutant) + FMN + methyl propenyl phenol <br />
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[[4ge8]], [[3txz]], [[4gwe]], [[4h4i]], [[4k7v]], [[4k8e]] – yOYE (mutant) + FMN + carvone <br />
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[[3tx9]] – yOYE + FMN + hydroxymethyl cyclopent-2-en-one <br />
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}}
== References ==
== References ==

Current revision

Structure of yeast NADPH dehydrogenase complex with FMN, p-hydroxybenzaldehyde and Mg+2 ion (green) (PDB code 1k03).

Drag the structure with the mouse to rotate

3D Structures of NADPH dehydrogenase

Updated on 11-July-2023

References

  1. ↑ Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488
  2. ↑ Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200

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Michal Harel, Alexander Berchansky

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