This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ott

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:36, 21 February 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal Structure of the extracellular domain of the putative one component system BT4673 from B. thetaiotaomicron==
==Crystal Structure of the extracellular domain of the putative one component system BT4673 from B. thetaiotaomicron==
-
<StructureSection load='3ott' size='340' side='right' caption='[[3ott]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='3ott' size='340' side='right'caption='[[3ott]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ott]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OTT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ott]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OTT FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BT_4673 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=818 "Bacillus thetaiotaomicron" Distaso 1912])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ott FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ott OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ott RCSB], [http://www.ebi.ac.uk/pdbsum/3ott PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ott FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ott OCA], [https://pdbe.org/3ott PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ott RCSB], [https://www.ebi.ac.uk/pdbsum/3ott PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ott ProSAT]</span></td></tr>
-
<table>
+
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/Q89YQ8_BACTN Q89YQ8_BACTN]
-
The adult human gut presents a complicated ecosystem where host-bacterium symbiosis plays an important role. Bacteroides thetaiotaomicron is a predominant member of the gut microflora, providing the human digestive tract with a large number of glycolytic enzymes. Expression of many of these enzymes appears to be controlled by histidine kinase receptors that are fused into unusual hybrid two-component systems that share homologous periplasmic sensor domains. These sensor domains belong to the third most populated (HK3) family based on a previous bioinformatics analysis of predicted histidine kinase sensors. Here, we present crystal structures of two sensor domains representative of the HK3 family. Each sensor is folded into three domains: two seven-bladed beta-propeller domains and one beta-sandwich domain. Both sensors form dimers in crystals and one sensor appears to be physiologically relevant. The folding characteristics in the individual domains, the domain organization, and the oligomeric architecture are all unique to the HK3 sensors. The sequence analysis of the HK3 sensors indicates that these sensors are shared among other signaling molecules, implying a combinatorial molecular evolution. This article is protected by copyright. All rights reserved.
+
-
 
+
-
Crystal Structures of Apparent Saccharide Sensors from Histidine Kinase Receptors Prevalent in a Human Gut Symbiont.,Zhang Z, Liu Q, Hendrickson WA FEBS J. 2014 Jul 3. doi: 10.1111/febs.12904. PMID:24995510<ref>PMID:24995510</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus thetaiotaomicron distaso 1912]]
+
[[Category: Bacteroides thetaiotaomicron]]
-
[[Category: Hendrickson, W A.]]
+
[[Category: Large Structures]]
-
[[Category: Liu, Q.]]
+
[[Category: Hendrickson WA]]
-
[[Category: Zhang, Z.]]
+
[[Category: Liu Q]]
-
[[Category: Beta-propeller]]
+
[[Category: Zhang Z]]
-
[[Category: Beta-sandwich]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal Structure of the extracellular domain of the putative one component system BT4673 from B. thetaiotaomicron

PDB ID 3ott

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ott"
Personal tools