4u0l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D131A-D133A== | |
| + | <StructureSection load='4u0l' size='340' side='right'caption='[[4u0l]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4u0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U0L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0l OCA], [https://pdbe.org/4u0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u0l RCSB], [https://www.ebi.ac.uk/pdbsum/4u0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP. | ||
| - | + | ==See Also== | |
| - | + | *[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio cholerae O1 biovar El Tor str. N16961]] | ||
| + | [[Category: Xiang Y]] | ||
| + | [[Category: Zhu DY]] | ||
Current revision
Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D131A-D133A
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