4uny
From Proteopedia
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==Structure of the A_Equine_Newmarket_2_93 H3 haemagglutinin in complex with 6SO4-3SLN== | ==Structure of the A_Equine_Newmarket_2_93 H3 haemagglutinin in complex with 6SO4-3SLN== | ||
- | <StructureSection load='4uny' size='340' side='right' caption='[[4uny]], [[Resolution|resolution]] 2.90Å' scene=''> | + | <StructureSection load='4uny' size='340' side='right'caption='[[4uny]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4uny]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNY OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4uny]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/canine/Colorado/17864/2006(H3N8)) Influenza A virus (A/canine/Colorado/17864/2006(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UNY FirstGlance]. <br> |
- | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |
- | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uny OCA], [https://pdbe.org/4uny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uny RCSB], [https://www.ebi.ac.uk/pdbsum/4uny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uny ProSAT]</span></td></tr> |
- | + | </table> | |
- | <table> | + | == Function == |
+ | [https://www.uniprot.org/uniprot/Q82847_9INFA Q82847_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
+ | <div class="pdbe-citations 4uny" style="background-color:#fffaf0;"></div> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: Collins | + | [[Category: Large Structures]] |
- | [[Category: Gamblin | + | [[Category: Collins PJ]] |
- | [[Category: Haire | + | [[Category: Gamblin SJ]] |
- | [[Category: Martin | + | [[Category: Haire LF]] |
- | [[Category: Ogrodowicz | + | [[Category: Martin SR]] |
- | [[Category: Skehel | + | [[Category: Ogrodowicz RW]] |
- | [[Category: Vachieri | + | [[Category: Skehel JJ]] |
- | [[Category: Walker | + | [[Category: Vachieri SG]] |
- | [[Category: Xiong | + | [[Category: Walker PA]] |
- | + | [[Category: Xiong X]] | |
- | + |
Current revision
Structure of the A_Equine_Newmarket_2_93 H3 haemagglutinin in complex with 6SO4-3SLN
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Categories: Large Structures | Collins PJ | Gamblin SJ | Haire LF | Martin SR | Ogrodowicz RW | Skehel JJ | Vachieri SG | Walker PA | Xiong X