We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
2mn9
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==peptoid analogue of maculatin G15 - peptoid trans-Nleu at position 13== | ==peptoid analogue of maculatin G15 - peptoid trans-Nleu at position 13== | ||
| - | <StructureSection load='2mn9' size='340' side='right' caption='[[2mn9 | + | <StructureSection load='2mn9' size='340' side='right'caption='[[2mn9]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mn9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN9 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2mn9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ranoidea_genimaculata Ranoidea genimaculata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MN9 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4G:N-(2-METHYLPROPYL)GLYCINE'>I4G</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn9 OCA], [https://pdbe.org/2mn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mn9 RCSB], [https://www.ebi.ac.uk/pdbsum/2mn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mn9 ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCU11_RANGE MCU11_RANGE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The inclusion of peptoid monomers into antimicrobial peptides (AMPs) increases their proteolytic resistance, but introduces conformational flexibility (reduced hydrogen bonding ability and cis/trans isomerism). We here use NMR spectroscopy to answer how the insertion of a peptoid monomer influences the structure of a regular alpha-helical AMP upon interaction with a dodecyl phosphocholine (DPC) micelle. Insertion of [(2-methylpropyl)amino]acetic acid in maculatin-G15 shows that the structural change and conformational flexibility depends on the site of insertion. This is governed by the micelle interaction of the amphipathic helices flanking the peptoid monomer and the side chain properties of the peptoid and its preceding residue. | ||
| + | |||
| + | Structural features of peptoid-peptide hybrids in lipid-water interfaces.,Uggerhoj LE, Munk JK, Hansen PR, Guntert P, Wimmer R FEBS Lett. 2014 Aug 25;588(17):3291-7. doi: 10.1016/j.febslet.2014.07.016. Epub, 2014 Jul 22. PMID:25063337<ref>PMID:25063337</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2mn9" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ranoidea genimaculata]] |
| - | [[Category: | + | [[Category: Guentert P]] |
| - | [[Category: | + | [[Category: Uggerhoej LE]] |
| - | [[Category: | + | [[Category: Wimmer R]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
peptoid analogue of maculatin G15 - peptoid trans-Nleu at position 13
| |||||||||||
