1a0k
From Proteopedia
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==PROFILIN I FROM ARABIDOPSIS THALIANA== | ==PROFILIN I FROM ARABIDOPSIS THALIANA== | ||
| - | <StructureSection load='1a0k' size='340' side='right' caption='[[1a0k]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='1a0k' size='340' side='right'caption='[[1a0k]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1a0k]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1a0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0K FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0k OCA], [https://pdbe.org/1a0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0k RCSB], [https://www.ebi.ac.uk/pdbsum/1a0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0k ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRF1_ARATH PRF1_ARATH] Binds to actin monomers and regulates the organization of the actin cytoskeleton (PubMed:26574597). At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (PubMed:29861135). At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate (PubMed:29861135). Binds ACT1, ACT7 and ACT11 and inhibits actin polymerization (PubMed:26578694). Coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during axial cell expansion (PubMed:26574597). Binds G-actin and poly-L-proline in vitro (PubMed:19200149). Inhibits cell growth of various pathogenic fungal strains (PubMed:30056100). May play a role as antifungal proteins in the defense system against fungal pathogen attacks (PubMed:30056100).<ref>PMID:19200149</ref> <ref>PMID:26574597</ref> <ref>PMID:26578694</ref> <ref>PMID:29861135</ref> <ref>PMID:30056100</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0k_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0k_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0k ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1a0k" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Profilin 3D Structures|Profilin 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Huddler D]] |
| - | [[Category: Lindberg | + | [[Category: Lindberg U]] |
| - | [[Category: Schutt | + | [[Category: Schutt CE]] |
| - | [[Category: | + | [[Category: Shigeta Junior R]] |
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Current revision
PROFILIN I FROM ARABIDOPSIS THALIANA
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