Sarcosine oxidase

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{{STRUCTURE_3ad8| PDB=3ad8 | SIZE=400| SCENE= |right|CAPTION=Heterotetramer of sarcosine oxidase containing FAD, FMN and NAD showing α subunit (grey), β subunit (green), γ subunit (pink) and δ subunit (yellow). Complex with pyrrole-2-carboxylate, sulfate and Zn+2 ions (grey), [[3ad8]] }}
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<StructureSection load='3ad8' size='350' side='right' scene='' caption='Heterotetramer of sarcosine oxidase containing FAD, FMN and NAD showing α subunit (grey), β subunit (green), γ subunit (pink) and δ subunit (yellow). Complex with pyrrole-2-carboxylate, sulfate and Zn+2 ions (grey) [[3ad8]]'>
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'''Sarcosine oxidase''' (SOX) catalyzes the demethylation of sarcosine+O2+H4-tetrahydrofolate to produce glycine, hydrogen peroxide and 5, 10-methylene-tetrahydrofolate. Sarcosine metabolism can be the source of carbon and energy for many microorganisms. SOXs are found as monomers, heterodirmers and heterotetramers. Monomeric SOX uses FAD as cofactor. Heterotetrameric SOX uses FAD and FMN as cofactors.
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'''Sarcosine oxidase''' (SOX) catalyzes the demethylation of sarcosine+O2+H4-tetrahydrofolate to produce glycine, hydrogen peroxide and 5, 10-methylene-tetrahydrofolate. Sarcosine metabolism can be the source of carbon and energy for many microorganisms. SOXs are found as monomers, heterodirmers and heterotetramers<ref>PMID:24185971</ref>. Monomeric SOX uses FAD as cofactor. Heterotetrameric SOX uses FAD and FMN as cofactors.
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</StructureSection>
==3D structures of sarcosine oxidase==
==3D structures of sarcosine oxidase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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'''SOX monomer'''
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*Monomeric sarcosine oxidase
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[[1el5]], [[1el7]], [[1el8]], [[1el9]], [[1eli]], [[2gf3]] – BaSOX + inhibitor – ''Bacillus''<br />
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**[[1el5]], [[1el7]], [[1el8]], [[1el9]], [[1eli]], [[2gf3]] – BaSOX + inhibitor – ''Bacillus''<br />
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[[1l9c]], [[1l9d]], [[1l9e]], [[3bhf]], [[3bhk]], [[3m0o]], [[3m12]], [[3m13]] – BaSOX (mutant)<br />
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**[[1l9c]], [[1l9d]], [[1l9e]], [[3bhf]], [[3bhk]], [[3m0o]], [[3m12]], [[3m13]] – BaSOX (mutant)<br />
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[[2a89]], [[2gb0]], [[1zov]], [[3qsm]], [[3qss]] - BaSOX<br />
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**[[2a89]], [[2gb0]], [[1zov]], [[3qsm]], [[3qss]] - BaSOX<br />
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[[3qse]] – BaSOX + arcosine<br />
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**[[3qse]] – BaSOX + arcosine<br />
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**[[1y56]] – SOX + protein – ''Pyrococcus horikoshii''<br />
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**[[7exs]] – SOX (mutant) – ''Thermomicrobium roseum''<br />
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'''SOX heterotetramer'''
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*Sarcosine oxidase heterotetramer
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[[1vrq]] – CoSOX + folinic acid – ''Corynebacterium''<br />
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**[[1vrq]] – CoSOX + folinic acid – ''Corynebacterium''<br />
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[[3ad7]] – CoSOX + methylthio acetate<br />
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**[[3ad7]] – CoSOX + methylthio acetate<br />
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[[3ad8]] – CoSOX + pyrrole 2-carboxylate<br />
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**[[3ad8]] – CoSOX + pyrrole 2-carboxylate<br />
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[[3ada]] – CoSOX + sulfite<br />
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**[[3ada]] – CoSOX + sulfite<br />
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[[1x31]], [[3ad9]] – CoSOX<br />
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**[[1x31]], [[3ad9]] – CoSOX<br />
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[[2gag]], [[2gah]] – SOX + furoic acid – ''Stenotrophomonas maltophilia''
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**[[2gag]], [[2gah]] – SOX + furoic acid – ''Stenotrophomonas maltophilia''
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Heterotetramer of sarcosine oxidase containing FAD, FMN and NAD showing α subunit (grey), β subunit (green), γ subunit (pink) and δ subunit (yellow). Complex with pyrrole-2-carboxylate, sulfate and Zn+2 ions (grey) 3ad8

Drag the structure with the mouse to rotate

3D structures of sarcosine oxidase

Updated on 15-March-2022

References

  1. ↑ Suzuki H. Sarcosine oxidase: structure, function, and the application to creatinine determination. Amino Acids. 1994 Feb;7(1):27-43. doi: 10.1007/BF00808444. PMID:24185971 doi:http://dx.doi.org/10.1007/BF00808444

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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