Krebs cycle step 7
From Proteopedia
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(New page: <h2>Step 7 of the Krebs cycle: Fumarase</h2> Image:fumarase_2.jpg <p>Figure: Formation of L-Malate</p> <p>L-malate is formed out of fumarate by adding water to the double bond; there...) |
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Current revision
Step 7 of the Krebs cycle: Fumarase
Figure: Formation of L-Malate
L-malate is formed out of fumarate by adding water to the double bond; therefore, the reaction type is a hydration. The reaction process is unusual becaue the first step is the addition of OH-. As a result, a negativley charged carbanion is formed. The addition of the proton on the opposite side of the hydroxy group, leads to the formation of L-malate. The catalysing enzyme fumarase is highly stereospecific, which can be seen from the fact that only L-malate is formed as a product and not a mixture of D-malate and L-malate.
