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Tryptophan RNA-binding attenuation protein

From Proteopedia

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(New page: <StructureSection load='1utf' size='340' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with RNA and Trp (PDB code 1utf).' scene=''> == Functio...)
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<StructureSection load='2exs' size='350' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>
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<StructureSection load='1utf' size='340' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with RNA and Trp (PDB code [[1utf]]).' scene=''>
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== Function ==
== Function ==
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'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP.
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'''Tryptophan RNA-binding attenuation protein''' (TRAP) or '''transcription attenuation protein MtrB''' is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 tryptophan molecules to TRAP<ref>PMID:14687568</ref>.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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TRAP is composed of 11 identical subunits arranged in a <scene name='59/595823/Cv/4'>symmetrical ring</scene>. The <scene name='59/595823/Cv/3'>active site of TRAP</scene><ref>PMID:16698553</ref>. Water molecules are shown as red spheres.
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</StructureSection>
== 3D Structures of tryptophan RNA-binding attenuation protein ==
== 3D Structures of tryptophan RNA-binding attenuation protein ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[3aqd]] – GsTRAP – ''Geobacillus stearothermophilus''<br />
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*Tryptophan RNA-binding attenuation protein
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===TRAP complex with Trp===
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**[[3aqd]] – GsTRAP – ''Geobacillus stearothermophilus''<br />
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[[2zdo]], [[2exs]], [[2ext]], [[2zcz]], [[2zd0]] – GsTRAP + Trp<br />
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*Tryptophan RNA-binding attenuation protein binary complex with Trp
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[[1wap]], [[3zzq]] – BsTRAP + Trp – ''Bacillus subtilis''<br />
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[[4b27]] – BsTRAP (mutant) + Trp <br />
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[[3zte]] – TRAP + Trp – ''Bacillus licheniformis''<br />
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[[3zzl]] – TRAP + Trp – ''Bacillus halodurans''<br />
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===TRAP ternary complex with Trp===
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**[[2zdo]], [[2exs]], [[2ext]], [[2zcz]], [[2zd0]], [[3zzs]], [[1qaw]] – GsTRAP + Trp<br />
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**[[5eew]], [[5eex]], [[5eey]], [[5eez]], [[5ef0]], [[5ef1]], [[5ef2]], [[5ef3]] – GsTRAP + Trp – radiation damage<br />
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**[[1wap]], [[3zzq]] – BsTRAP + Trp – ''Bacillus subtilis''<br />
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**[[4b27]] – BsTRAP (mutant) + Trp <br />
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**[[3zte]] – TRAP + Trp – ''Bacillus licheniformis''<br />
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**[[3zzl]] – TRAP + Trp – ''Bacillus halodurans''<br />
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[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[1utf]], [[1utv]] – GsTRAP + RNA + Trp <br />
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*Tryptophan RNA-binding attenuation protein ternary complex with Trp
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[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />
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**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[4v4f]] – GsTRAP + RNA + Trp <br />
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**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code 2exs).

Drag the structure with the mouse to rotate

3D Structures of tryptophan RNA-binding attenuation protein

Updated on 21-December-2020

References

  1. ↑ Li PT, Gollnick P. Characterization of a trp RNA-binding attenuation protein (TRAP) mutant with tryptophan independent RNA binding activity. J Mol Biol. 2004 Jan 16;335(3):707-22. PMID:14687568 doi:http://dx.doi.org/10.1016/S0022283603013846
  2. ↑ Heddle JG, Yokoyama T, Yamashita I, Park SY, Tame JR. Rounding up: Engineering 12-membered rings from the cyclic 11-mer TRAP. Structure. 2006 May;14(5):925-33. PMID:16698553 doi:http://dx.doi.org/10.1016/j.str.2006.03.013

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