4u3e

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'''Unreleased structure'''
 
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The entry 4u3e is ON HOLD
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==Anaerobic ribonucleotide reductase==
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<StructureSection load='4u3e' size='340' side='right'caption='[[4u3e]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4u3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U3E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u3e OCA], [https://pdbe.org/4u3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u3e RCSB], [https://www.ebi.ac.uk/pdbsum/4u3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u3e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WYL6_THEMA Q9WYL6_THEMA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The class III anaerobic ribonucleotide reductases (RNRs) studied to date couple the reduction of ribonucleotides to deoxynucleotides with the oxidation of formate to CO2. Here we report the cloning and heterologous expression of the Neisseria bacilliformis class III RNR and show that it can catalyze nucleotide reduction using the ubiquitous thioredoxin/thioredoxin reductase/NADPH system. We present a structural model based on a crystal structure of the homologous Thermotoga maritima class III RNR, showing its architecture and the position of conserved residues in the active site. Phylogenetic studies suggest that this form of class III RNR is present in bacteria and archaea that carry out diverse types of anaerobic metabolism.
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Authors: Funk, M.A., Drennan, C.L.
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The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant.,Wei Y, Funk MA, Rosado LA, Baek J, Drennan CL, Stubbe J Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3756-65. doi:, 10.1073/pnas.1414396111. Epub 2014 Aug 25. PMID:25157154<ref>PMID:25157154</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4u3e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Thermotoga maritima]]
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[[Category: Drennan CL]]
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[[Category: Funk MA]]

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Anaerobic ribonucleotide reductase

PDB ID 4u3e

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