4u5a
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4u5a is ON HOLD Authors: Hamaoka, B.Y. Description: Sporozoite Protein for Cell Traversal) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Sporozoite Protein for Cell Traversal== | |
| + | <StructureSection load='4u5a' size='340' side='right'caption='[[4u5a]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4u5a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5A FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5a OCA], [https://pdbe.org/4u5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5a RCSB], [https://www.ebi.ac.uk/pdbsum/4u5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q75UY1_PLABE Q75UY1_PLABE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Host cell traversal by Plasmodium, the protozoan cause of malaria, is an essential part of this parasite's virulence. In this process, the parasite enters a host cell through a parasite-induced pore, traverses the host cell, and then exits the host cell. Two P. berghei proteins, SPECT1 and SPECT2, are required for host cell traversal by the sporozoite form of the parasite. In the absence of either, no pore formation is observed. While SPECT2 has sequence homology to pore-forming proteins, SPECT1 has no homology to proteins of known structure or function. Here we present the 2.75 A resolution structure of a slightly truncated version of P. berghei SPECT1. The structure reveals that the protein forms a four-helix bundle, with the rare feature of having all of these helices in parallel or antiparallel alignment. Also notable is the presence of a large, conserved, hydrophobic internal cavity in the protein, which may constitute a ligand-binding site or be indicative of partial instability in SPECT1, or both. The structure of SPECT1 will make possible targeted mutagenesis experiments aimed at understanding its mechanism of action in host cell traversal. | ||
| - | + | Structure of the Essential Plasmodium Host Cell Traversal Protein SPECT1.,Hamaoka BY, Ghosh P PLoS One. 2014 Dec 5;9(12):e114685. doi: 10.1371/journal.pone.0114685., eCollection 2014. PMID:25479287<ref>PMID:25479287</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4u5a" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium berghei]] | ||
| + | [[Category: Hamaoka BY]] | ||
Current revision
Sporozoite Protein for Cell Traversal
| |||||||||||
