4u5h
From Proteopedia
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(New page: '''Unreleased structure''' The entry 4u5h is ON HOLD Authors: Chen,L., Gouaux,E. Description:) |
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| - | '''Unreleased structure''' | ||
| - | + | ==crystal structure of con-ikot-ikot toxin== | |
| + | <StructureSection load='4u5h' size='340' side='right'caption='[[4u5h]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4u5h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5h OCA], [https://pdbe.org/4u5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5h RCSB], [https://www.ebi.ac.uk/pdbsum/4u5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CONII_CONST CONII_CONST] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | AMPA-sensitive glutamate receptors are crucial to the structural and dynamical properties of the brain, to the development and function of the central nervous system, and to the treatment of neurological conditions from depression to cognitive impairment. However, the molecular principles underlying AMPA receptor activation have remained elusive. Here, we determine multiple x-ray crystal structures of the GluA2 AMPA receptor in complex with a Conus striatus cone snail toxin, a positive allosteric modulator, and orthosteric agonists, at 3.8 to 4.1 angstrom resolution. We show how the toxin acts like a "straight jacket" on the ligand-binding domain (LBD) "gating ring," restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD "clamshells" is transduced into an irislike expansion of the gating ring. By structural analysis of activation-enhancing mutants, we show how the expansion of the LBD gating ring results in "pulling" forces on the M3 helices that, in turn, are coupled to ion channel gating. | ||
| - | + | X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.,Chen L, Duerr KL, Gouaux E Science. 2014 Aug 7. pii: 1258409. PMID:25103405<ref>PMID:25103405</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4u5h" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conus striatus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen L]] | ||
| + | [[Category: Gouaux E]] | ||
Current revision
crystal structure of con-ikot-ikot toxin
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