This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4qmc
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of complex formed between phospholipase A2 and Biotin-sulfoxide at 1.09 A Resolution== | ==Crystal structure of complex formed between phospholipase A2 and Biotin-sulfoxide at 1.09 A Resolution== | ||
| - | <StructureSection load='4qmc' size='340' side='right' caption='[[4qmc]], [[Resolution|resolution]] 1.09Å' scene=''> | + | <StructureSection load='4qmc' size='340' side='right'caption='[[4qmc]], [[Resolution|resolution]] 1.09Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4qmc]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4qmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QMC FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qmc OCA], [https://pdbe.org/4qmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qmc RCSB], [https://www.ebi.ac.uk/pdbsum/4qmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qmc ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Daboia | + | [[Category: Daboia russelii pulchella]] |
| - | [[Category: Kaur | + | [[Category: Large Structures]] |
| - | [[Category: Sharma | + | [[Category: Kaur P]] |
| - | [[Category: Shukla | + | [[Category: Sharma S]] |
| - | [[Category: Singh | + | [[Category: Shukla PK]] |
| - | [[Category: Sinha | + | [[Category: Singh TP]] |
| - | + | [[Category: Sinha M]] | |
Current revision
Crystal structure of complex formed between phospholipase A2 and Biotin-sulfoxide at 1.09 A Resolution
| |||||||||||
