Fibritin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1ox3' size='340' side='right' caption='Structure of fibritin N-terminal and foldon domains )PDB code 1ox3).' scene=''> == Function == '''Fibritin''' (Fib) is...) |
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| - | + | <StructureSection load='1ox3' size='340' side='right' caption='Structure of fibritin N-terminal and foldon domains (PDB code [[1ox3]]).' scene='59/596418/Cv/1'> | |
| - | <StructureSection load='1ox3' size='340' side='right' caption='Structure of fibritin N-terminal and foldon domains | + | |
== Function == | == Function == | ||
| - | '''Fibritin''' (Fib) is a | + | '''Fibritin''' (Fib) is a structural protein of virus. Fib promotes the assembly of the long tail fibers (whiskers) and their attachment to the virus tail baseplate. Fib is also responsible for the retraction of the tail fibers in adverse environment<ref>PMID:9261070</ref>. |
| - | == | + | == Structural highlights == |
| - | = | + | <scene name='59/596418/Cv/3'>Fib is trimer</scene>. Fib structure is composed of N-terminal domain which is responsible for attachment to the phage, a central 500A domain made of triple-helix coiled coil and the C-terminal domain ('''foldon''') – residues 458-484 – which is the trimerization domain. |
| - | + | </StructureSection> | |
==3D structures of fibritin== | ==3D structures of fibritin== | ||
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[[1aa0]] – T4Fib residues 371-483 – T4 bacteriophage<br /> | [[1aa0]] – T4Fib residues 371-483 – T4 bacteriophage<br /> | ||
[[1avy]] – T4Fib residues 413-486 (mutant)<br /> | [[1avy]] – T4Fib residues 413-486 (mutant)<br /> | ||
| - | [[2ww6]], [[2ww7]], [[4ncu]], [[4ncv]], [[4ncw]] – T4Fib foldon <br /> | + | [[2ww6]], [[2ww7]], [[4ncu]], [[4ncv]], [[4ncw]] – T4Fib foldon 458-484<br /> |
[[1u0p]] – T4Fib foldon - NMR<br /> | [[1u0p]] – T4Fib foldon - NMR<br /> | ||
[[1rfo]], [[2kbl]] – T4Fib foldon (mutant) - NMR<br /> | [[1rfo]], [[2kbl]] – T4Fib foldon (mutant) - NMR<br /> | ||
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[[1v1h]], [[1v1i]] – Fib shaft domain/T4Fib foldon domain - Adenovirus<br /> | [[1v1h]], [[1v1i]] – Fib shaft domain/T4Fib foldon domain - Adenovirus<br /> | ||
[[3a1m]] – T4Fib foldon/GP5C <br /> | [[3a1m]] – T4Fib foldon/GP5C <br /> | ||
| + | [[6z97]] – ScvFib – SARS coronavirus – Cryo EM<br /> | ||
| + | [[6crv]], [[6crw]], [[6crx]], [[6crz]], [[6cs0]], [[6cs1]], [[6cs2]] – ScvFib (mutant) <br /> | ||
Current revision
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3D structures of fibritin
Updated on 28-July-2020
2bsg, 3j2o – T4Fib – T4 bacteriophage – Cryo-EM
1aa0 – T4Fib residues 371-483 – T4 bacteriophage
1avy – T4Fib residues 413-486 (mutant)
2ww6, 2ww7, 4ncu, 4ncv, 4ncw – T4Fib foldon 458-484
1u0p – T4Fib foldon - NMR
1rfo, 2kbl – T4Fib foldon (mutant) - NMR
1ox3 – T4Fib N-terminal + foldon domains
2ibl – Fib N-terminal + foldon domains – unidentified phage
1v1h, 1v1i – Fib shaft domain/T4Fib foldon domain - Adenovirus
3a1m – T4Fib foldon/GP5C
6z97 – ScvFib – SARS coronavirus – Cryo EM
6crv, 6crw, 6crx, 6crz, 6cs0, 6cs1, 6cs2 – ScvFib (mutant)
