1d7i

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[[Image:1d7i.gif|left|200px]]
 
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{{Structure
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==FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)==
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|PDB= 1d7i |SIZE=350|CAPTION= <scene name='initialview01'>1d7i</scene>, resolution 1.90&Aring;
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<StructureSection load='1d7i' size='340' side='right'caption='[[1d7i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=DSS:METHYL METHYLSULFINYLMETHYL SULFIDE'>DSS</scene>
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<table><tr><td colspan='2'>[[1d7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D7I FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSS:METHYL+METHYLSULFINYLMETHYL+SULFIDE'>DSS</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d7i OCA], [https://pdbe.org/1d7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d7i RCSB], [https://www.ebi.ac.uk/pdbsum/1d7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d7i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d7/1d7i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d7i ConSurf].
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<div style="clear:both"></div>
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'''FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)'''
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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==Overview==
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<references/>
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A new crystal form of native FK506 binding protein (FKBP) has been obtained which has proved useful in ligand binding studies. Three different small molecule ligand complexes and the native enzyme have been determined at higher resolution than 2.0 A. Dissociation constants of the related small molecule ligands vary from 20 mM for dimethylsulphoxide to 200 microM for tetrahydrothiophene 1-oxide. Comparison of the four available crystal structures shows that the protein structures are identical to within experimental error, but there are differences in the water structure in the active site. Analysis of the calculated buried surface areas of these related ligands provides an estimated van der Waals contribution to the binding energy of -0.5 kJ/A(2) for non-polar interactions between ligand and protein.
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__TOC__
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</StructureSection>
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==About this Structure==
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1D7I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7I OCA].
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==Reference==
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X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies., Burkhard P, Taylor P, Walkinshaw MD, J Mol Biol. 2000 Jan 28;295(4):953-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10656803 10656803]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Burkhard P]]
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[[Category: Burkhard, P.]]
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[[Category: Taylor P]]
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[[Category: Taylor, P.]]
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[[Category: Walkinshaw MD]]
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[[Category: Walkinshaw, M D.]]
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[[Category: DSS]]
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[[Category: NH4]]
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[[Category: SO4]]
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[[Category: dss]]
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[[Category: fkbp]]
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[[Category: immunophilin]]
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[[Category: isomerase]]
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[[Category: methyl methylsulfinylmethyl sulfide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:33:58 2008''
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Current revision

FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)

PDB ID 1d7i

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