Sandbox bcce11
From Proteopedia
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==Human P-glycoprotein== | ==Human P-glycoprotein== | ||
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<StructureSection load='3G61' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3G61' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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Human P-glycoprotein (ABCB1, P-gp) is a membrane protein present primarily in sanctuary sites, such as the blood-brain barrier, blood-testes barrier, placenta, and gut. The exact mechanism and quantity of molecules bound to P-gp during one transport cycle has not been confirmed experimentally, however recent advances in structural information have begun to reveal a more detailed image of subtrate binding to P-gp <ref>PMID:19325113</ref> | Human P-glycoprotein (ABCB1, P-gp) is a membrane protein present primarily in sanctuary sites, such as the blood-brain barrier, blood-testes barrier, placenta, and gut. The exact mechanism and quantity of molecules bound to P-gp during one transport cycle has not been confirmed experimentally, however recent advances in structural information have begun to reveal a more detailed image of subtrate binding to P-gp <ref>PMID:19325113</ref> | ||
| - | [[Image:Jsmol.gif|300 px|]] | + | [[Image:Jsmol.gif|300 px|]] |
| + | (Image showing inhibitor bound to P-gp.) | ||
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| + | <scene name='59/596453/Ligand/1'>Ligand bound to P-gp</scene> | ||
| + | <scene name='59/596453/Ligand/2'>Ligand zoom</scene> | ||
| + | <scene name='59/596453/Ligand/3'>No rotation</scene> | ||
== Function == | == Function == | ||
Current revision
Human P-glycoprotein
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References
- ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718
