Sandbox bcce14
From Proteopedia
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
[[Image:picture.jpg]] | [[Image:picture.jpg]] | ||
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== Function == | == Function == | ||
| - | This protein is a tyrosine kinase that is active in the progression of a cell through the G2/M checkpoint. | + | This protein is a tyrosine kinase that is active in the progression of a cell through the G2/M checkpoint. |
| + | [[Image:Cell_cycle_check_points.jpg]] | ||
== Disease == | == Disease == | ||
Mutations in the C terminal end of the protein have been associated with excessive kinase activity. It has been implicated in aggressive forms of breast cancer. | Mutations in the C terminal end of the protein have been associated with excessive kinase activity. It has been implicated in aggressive forms of breast cancer. | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='59/596448/N_to_c_rainbow/2'>N to C sequence</scene> | <scene name='59/596448/N_to_c_rainbow/2'>N to C sequence</scene> | ||
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{{Template:ColorKey_Amino2CarboxyRainbow}} | {{Template:ColorKey_Amino2CarboxyRainbow}} | ||
<scene name='59/596448/Secondary_structure/1'>Secondary Structures</scene> | <scene name='59/596448/Secondary_structure/1'>Secondary Structures</scene> | ||
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{{Template:ColorKey_Strand}} | {{Template:ColorKey_Strand}} | ||
{{Template:ColorKey_Turn}} | {{Template:ColorKey_Turn}} | ||
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| + | <scene name='59/596448/Hydrophobic_hydrophilic_residu/1'>hydrophobic and hydrophilic residues</scene> | ||
| + | {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}} | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Current revision
BCCE14: The amazing protein
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
