Sandbox bcce34

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Focal adhesion kinase has four defined regions, or tertiary structure domains. Two of these domains, the N-terminal FERM domain and the Kinase domain form an auto-inhibitory interaction. This interaction is thought to be the result of hydrophobic interactions between the two domains and prevents the activation of the Kinase domain, FAK, thereby preventing the signalling function of FAK. Release of this auto-inhibitory interaction has been shown to occur within focal adhesions but not in the cytoplasm and therefore is thought to require interaction with focal adhesion proteins, potentially as a result of mechanical forces transmitted through the focal adhesion.
Focal adhesion kinase has four defined regions, or tertiary structure domains. Two of these domains, the N-terminal FERM domain and the Kinase domain form an auto-inhibitory interaction. This interaction is thought to be the result of hydrophobic interactions between the two domains and prevents the activation of the Kinase domain, FAK, thereby preventing the signalling function of FAK. Release of this auto-inhibitory interaction has been shown to occur within focal adhesions but not in the cytoplasm and therefore is thought to require interaction with focal adhesion proteins, potentially as a result of mechanical forces transmitted through the focal adhesion.
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<scene name='59/596497/Ligand-receptor_complex/1'>Ligand - Receptor complex</scene>
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<scene name='59/596497/Fak_atp/1'>FAK - ATP</scene>
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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<scene name='59/596497/Ligand-receptor_complex/1'>Ligand - Receptor complex TAE226</scene>
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<scene name='59/596497/Ferm_domain/1'>FERM domain</scene>
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<scene name='59/596497/Ferm-kinase_domain/1'>FERM and Kinase domains</scene>
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<scene name='59/596497/Ferm-kinase_domain-color/1'>FERM and Kinase domains colored</scene>
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<scene name='59/596497/Fat_domain/1'>FAT domain</scene>
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Focal Adhesion Kinase (FAK)

FAK - Bis-Anilino Pyrimidine Inhibitor

Drag the structure with the mouse to rotate

References

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