1da5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:06, 10 April 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1da5.gif|left|200px]]
 
-
{{Structure
+
==Solution structure of a DNA Duplex containing the CIS-PT(NH3)2[D(-GTG-)-N7-(G)-N7(G)N7(G)]Adduct as determined with high field NMR And molecular mechanics/dynamics==
-
|PDB= 1da5 |SIZE=350|CAPTION= <scene name='initialview01'>1da5</scene>
+
<StructureSection load='1da5' size='340' side='right'caption='[[1da5]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CPT:CIS-PLATINUM-(NH3)2'>CPT</scene>
+
<table><tr><td colspan='2'>[[1da5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DA5 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1da5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1da5 OCA], [https://pdbe.org/1da5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1da5 RCSB], [https://www.ebi.ac.uk/pdbsum/1da5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1da5 ProSAT]</span></td></tr>
-
 
+
</table>
-
'''SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING THE CIS-PT(NH3)2[D(-GTG-)-N7-(G)-N7(G)N7(G)]ADDUCT AS DETERMINED WITH HIGH FIELD NMR AND MOLECULAR MECHANICS/DYNAMICS'''
+
__TOC__
-
 
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==Overview==
+
[[Category: Van Garderen CJ]]
-
The solution structure of the cis-Pt-GTG adduct in the double-stranded oligomer d(CTCTAGTGCTCAC).td(GTGAGCACTAGAG) was studied with high-resolution NMR techniques. For model building, the distance information obtained from two-dimensional NOE experiments was used in molecular mechanic computations and molecular dynamic structure refinements. The structural distortion upon platination appears to be restricted to the base pairs Pt-G6.C21 and T7.A20; Pt-G8.C19 forms a normal Watson-Crick base pair. T7 is positioned in the minor groove and stacks with the highly propeller-twisted Pt-G6. There is no hydrogen bonding between T7 and A20. The complementary strand is undistorted; A20 stacks with its flanking cytidines (C19 and C21) as in regular B-DNA. The duplex is locally unwound (from base pair A5.T22 to G8.C19: 19 degrees) and is slightly kinked (20 degrees) at the platination site. The platinum coordination distorts the DNA structure at the 5' side of the platinated-GTG-sequence and changes the minor groove face.
+
[[Category: Van Houte LPA]]
-
 
+
-
==About this Structure==
+
-
1DA5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA5 OCA].
+
-
 
+
-
==Reference==
+
-
The solution structure of a DNA duplex containing the cis-Pt(NH3)2[d(-GTG-)-N7(G),N7(G)] adduct, as determined with high-field NMR and molecular mechanics/dynamics., van Garderen CJ, van Houte LP, Eur J Biochem. 1994 Nov 1;225(3):1169-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7957208 7957208]
+
-
[[Category: Protein complex]]
+
-
[[Category: Garderen, C J.Van.]]
+
-
[[Category: Houte, L P.A Van.]]
+
-
[[Category: CPT]]
+
-
[[Category: dna]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:35:13 2008''
+

Current revision

Solution structure of a DNA Duplex containing the CIS-PT(NH3)2[D(-GTG-)-N7-(G)-N7(G)N7(G)]Adduct as determined with high field NMR And molecular mechanics/dynamics

PDB ID 1da5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1da5"
Personal tools