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| - | ==CRYSTAL STRUCTURE DERIVED MODELS OF ADENOVIRUS CEMENT PROTEINS AT 3.8A==
| + | #REDIRECT [[6cgv]] This PDB entry is obsolete and replaced by 6cgv |
| - | <StructureSection load='4cwu' size='340' side='right' caption='[[4cwu]], [[Resolution|resolution]] 3.80Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4cwu]] is a 23 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWU FirstGlance]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwu RCSB], [http://www.ebi.ac.uk/pdbsum/4cwu PDBsum]</span></td></tr>
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| - | <table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | Adenovirus cement proteins play crucial roles in virion assembly, disassembly, cell entry, and infection. Based on a refined crystal structure of the adenovirus virion at 3.8-A resolution, we have determined the structures of all of the cement proteins (IIIa, VI, VIII, and IX) and their organization in two distinct layers. We have significantly revised the recent cryoelectron microscopy models for proteins IIIa and IX and show that both are located on the capsid exterior. Together, the cement proteins exclusively stabilize the hexon shell, thus rendering penton vertices the weakest links of the adenovirus capsid. We describe, for the first time to our knowledge, the structure of protein VI, a key membrane-lytic molecule, and unveil its associations with VIII and core protein V, which together glue peripentonal hexons beneath the vertex region and connect them to the rest of the capsid on the interior. Following virion maturation, the cleaved N-terminal propeptide of VI is observed, reaching deep into the peripentonal hexon cavity, detached from the membrane-lytic domain, so that the latter can be released. Our results thus provide the molecular basis for the requirement of maturation cleavage of protein VI. This process is essential for untethering and release of the membrane-lytic region, which is known to mediate endosome rupture and delivery of partially disassembled virions into the host cell cytoplasm.
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| - | Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection.,Reddy VS, Nemerow GR Proc Natl Acad Sci U S A. 2014 Jul 28. pii: 201408462. PMID:25071205<ref>PMID:25071205</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Nemerow, G R.]]
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| - | [[Category: Reddy, V S.]]
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| - | [[Category: Adenovirus]]
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| - | [[Category: Cement protein]]
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| - | [[Category: Protein vi]]
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| - | [[Category: Virus]]
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