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4nwd

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==Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution==
==Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution==
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<StructureSection load='4nwd' size='340' side='right' caption='[[4nwd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4nwd' size='340' side='right'caption='[[4nwd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nwd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nwd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NWD FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2QD:(4R)-4-[3-(METHYLAMINO)-3-OXOPROPYL]-L-GLUTAMIC+ACID'>2QD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s9e|3s9e]], [[4mh5|4mh5]], [[4nwc|4nwc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2QD:(4R)-4-[3-(METHYLAMINO)-3-OXOPROPYL]-L-GLUTAMIC+ACID'>2QD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nwd RCSB], [http://www.ebi.ac.uk/pdbsum/4nwd PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwd OCA], [https://pdbe.org/4nwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nwd RCSB], [https://www.ebi.ac.uk/pdbsum/4nwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwd ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nwd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Frydenvang, K.]]
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[[Category: Large Structures]]
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[[Category: Gajhede, M.]]
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[[Category: Rattus norvegicus]]
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[[Category: Kastrup, J S.]]
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[[Category: Frydenvang K]]
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[[Category: Larsen, A P.]]
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[[Category: Gajhede M]]
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[[Category: Venskutonyte, R.]]
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[[Category: Kastrup JS]]
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[[Category: Agonist]]
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[[Category: Larsen AP]]
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[[Category: Ionotropic glutamate receptor]]
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[[Category: Venskutonyte R]]
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[[Category: Kainate receptor]]
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[[Category: Ligand binding domain]]
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[[Category: Membrabe protein-agonist complex]]
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[[Category: Membrane protein-agonist complex]]
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Current revision

Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution

PDB ID 4nwd

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