4d09
From Proteopedia
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==PDE2a catalytic domain in complex with a brain penetrant inhibitor== | ==PDE2a catalytic domain in complex with a brain penetrant inhibitor== | ||
| - | <StructureSection load='4d09' size='340' side='right' caption='[[4d09]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='4d09' size='340' side='right'caption='[[4d09]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4d09]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4d09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D09 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d09 OCA], [https://pdbe.org/4d09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d09 RCSB], [https://www.ebi.ac.uk/pdbsum/4d09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d09 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref> | ||
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| + | ==See Also== | ||
| + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Andres | + | [[Category: Large Structures]] |
| - | [[Category: Buijnsters | + | [[Category: Andres JI]] |
| - | [[Category: DeAngelis | + | [[Category: Buijnsters P]] |
| - | [[Category: Langlois | + | [[Category: DeAngelis M]] |
| - | [[Category: Rombouts | + | [[Category: Langlois X]] |
| - | [[Category: Sanderson | + | [[Category: Rombouts F]] |
| - | [[Category: Trabanco | + | [[Category: Sanderson W]] |
| - | [[Category: Tresadern | + | [[Category: Trabanco A]] |
| - | [[Category: VanHoof | + | [[Category: Tresadern G]] |
| - | [[Category: VanRoosbroeck | + | [[Category: VanHoof G]] |
| - | + | [[Category: VanRoosbroeck Y]] | |
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Current revision
PDE2a catalytic domain in complex with a brain penetrant inhibitor
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