1dd5

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[[Image:1dd5.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA RIBOSOME RECYCLING FACTOR, RRF==
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|PDB= 1dd5 |SIZE=350|CAPTION= <scene name='initialview01'>1dd5</scene>, resolution 2.55&Aring;
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<StructureSection load='1dd5' size='340' side='right'caption='[[1dd5]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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<table><tr><td colspan='2'>[[1dd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD5 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd5 OCA], [https://pdbe.org/1dd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd5 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RRF_THEMA RRF_THEMA] Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1dd5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dd5 ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA RIBOSOME RECYCLING FACTOR, RRF'''
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==See Also==
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*[[Ribosome recycling factor|Ribosome recycling factor]]
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__TOC__
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==Overview==
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</StructureSection>
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Ribosome recycling factor (RRF), together with elongation factor G (EF-G), catalyzes recycling of ribosomes after one round of protein synthesis. The crystal structure of RRF was determined at 2.55 angstrom resolution. The protein has an unusual fold where domain I is a long three-helix bundle and domain II is a three-layer beta/alpha/beta sandwich. The molecule superimposes almost perfectly with a transfer RNA (tRNA) except that the amino acid-binding 3' end is missing. The mimicry suggests that RRF interacts with the posttermination ribosomal complex in a similar manner to a tRNA, leading to disassembly of the complex. The structural arrangement of this mimicry is entirely different from that of other cases of less pronounced mimicry of tRNA so far described.
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[[Category: Large Structures]]
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==About this Structure==
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1DD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD5 OCA].
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==Reference==
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Crystal structure of Thermotoga maritima ribosome recycling factor: a tRNA mimic., Selmer M, Al-Karadaghi S, Hirokawa G, Kaji A, Liljas A, Science. 1999 Dec 17;286(5448):2349-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600747 10600747]
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[[Category: Single protein]]
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Al-Karadaghi, S.]]
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[[Category: Al-Karadaghi S]]
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[[Category: Hirokawa, G.]]
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[[Category: Hirokawa G]]
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[[Category: Kaji, A.]]
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[[Category: Kaji A]]
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[[Category: Liljas, A.]]
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[[Category: Liljas A]]
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[[Category: Selmer, M.]]
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[[Category: Selmer M]]
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[[Category: ACY]]
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[[Category: beta-alpha-beta sandwich]]
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[[Category: three-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:36:35 2008''
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Current revision

CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA RIBOSOME RECYCLING FACTOR, RRF

PDB ID 1dd5

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