Trehalulose synthase
From Proteopedia
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(New page: <StructureSection load='2pwe' size='340' side='right' caption='Structure of trehalulose synthase complex with sucrose (PDB code 2pwe).' scene=''> == Function == '''Trehalulose synth...) |
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| - | + | <StructureSection load='2pwe' size='350' side='right' caption='Structure of trehalulose synthase complex with sucrose and Ca+2 ion (green) (PDB code [[2pwe]]).' scene='59/597011/Cv/1'> | |
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== Function == | == Function == | ||
| - | '''Trehalulose synthase''' (THS) converts sucrose to trehalulose (TH). | + | '''Trehalulose synthase''' or '''sucrose isomerase''' (THS) converts sucrose to trehalulose (TH)<ref>PMID:7878741</ref>. |
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== Relevance == | == Relevance == | ||
| - | Since TH is a sugar substitute and is absorbed more slowly than sucrose it can be used in diabetic and sports food and drinks. | + | Since TH is a sugar substitute and is absorbed more slowly than sucrose it can be used in diabetic and sports food and drinks<ref>PMID:18685525</ref>. |
== Structural highlights == | == Structural highlights == | ||
| + | <scene name='59/597011/Cv/5'>THS binds sucrose</scene> (water molecules are shown as red spheres) in a <scene name='59/597011/Cv/6'>deep pocket</scene> with mostly conserved residues<ref>PMID:17597061</ref>. | ||
| + | </StructureSection> | ||
==3D structures of trehalulose synthase== | ==3D structures of trehalulose synthase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Trehalulose synthase | |
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| - | + | **[[1zja]], [[1zjb]], [[2pwh]] – PmTHS – ''Pseudomonas mesoacidophila''<br /> | |
| + | **[[4go9]], [[4go8]] – PmTHS (mutant) <br /> | ||
| + | **[[4h2c]], [[4h8h]] – RhTHS (mutant) - ''Rhizobium''<br /> | ||
| + | **[[3gbd]] – PrTHS – ''Protaminobacter rubrum''<br /> | ||
| + | **[[4how]] – ErTHS – ''Erwinia rhapontici''<br /> | ||
| - | + | *Trehalulose synthase complex | |
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| + | **[[2pwd]], [[2pwg]] – PmTHS + inhibitor<br /> | ||
| + | **[[2pwe]] – PmTHS (mutant) + sucrose<br /> | ||
| + | **[[2pwf]] – PmTHS (mutant) + glucose<br /> | ||
| + | **[[4hoz]] – ErTHS + glucose<br /> | ||
| + | **[[4hph]] – ErTHS + sucrose<br /> | ||
| + | **[[4gi6]], [[4h7v]] – RhTHS (mutant) + glucose <br /> | ||
| + | **[[4gi8]] – RhTHS (mutant) + sucrose<br /> | ||
| + | **[[4h8v]] – RhTHS + TH<br /> | ||
| + | **[[4gi9]] – RhTHS (mutant) + TH<br /> | ||
| + | **[[4h8u]] – RhTHS (mutant) + sucrose + TH<br /> | ||
| + | **[[4gia]], [[4ha1]] – RhTHS (mutant) + isomaltulose<br /> | ||
| + | **[[4gin]] – RhTHS (mutant) + inhibitor<br /> | ||
| + | **[[3gbe]] – PrTHS + inhibitor<br /> | ||
| + | }} | ||
== References == | == References == | ||
Current revision
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3D structures of trehalulose synthase
Updated on 16-December-2020
References
- ↑ Thevelein JM, Hohmann S. Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci. 1995 Jan;20(1):3-10. PMID:7878741
- ↑ Venables MC, Brouns F, Jeukendrup AE. Oxidation of maltose and trehalose during prolonged moderate-intensity exercise. Med Sci Sports Exerc. 2008 Sep;40(9):1653-9. doi: 10.1249/MSS.0b013e318175716c. PMID:18685525 doi:http://dx.doi.org/10.1249/MSS.0b013e318175716c
- ↑ Ravaud S, Robert X, Watzlawick H, Haser R, Mattes R, Aghajari N. Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization. J Biol Chem. 2007 Sep 21;282(38):28126-36. Epub 2007 Jun 27. PMID:17597061 doi:10.1074/jbc.M704515200
