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3zgf

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==Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with in complex with NPE caged UDP-Gal (P2(1)2(1)2(1) space group)==
==Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with in complex with NPE caged UDP-Gal (P2(1)2(1)2(1) space group)==
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<StructureSection load='3zgf' size='340' side='right' caption='[[3zgf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3zgf' size='340' side='right'caption='[[3zgf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IUG:1-(2-NITROPHENYL)ETHYL+UDP-GALACTOSE'>IUG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zgg|3zgg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUG:1-(2-NITROPHENYL)ETHYL+UDP-GALACTOSE'>IUG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zgf RCSB], [http://www.ebi.ac.uk/pdbsum/3zgf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgf OCA], [https://pdbe.org/3zgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgf RCSB], [https://www.ebi.ac.uk/pdbsum/3zgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgf ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3zgf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Batot, G O.]]
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[[Category: Large Structures]]
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[[Category: Breton, C.]]
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[[Category: Batot GO]]
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[[Category: Hindsgaul, O.]]
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[[Category: Breton C]]
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[[Category: Imberty, A.]]
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[[Category: Hindsgaul O]]
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[[Category: Jorgensen, R.]]
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[[Category: Imberty A]]
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[[Category: Palcic, M M.]]
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[[Category: Jorgensen R]]
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[[Category: Perez, S.]]
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[[Category: Palcic MM]]
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[[Category: Royant, A.]]
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[[Category: Perez S]]
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[[Category: Tanaka, H.]]
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[[Category: Royant A]]
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[[Category: Glycosyltransferase]]
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[[Category: Tanaka H]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with in complex with NPE caged UDP-Gal (P2(1)2(1)2(1) space group)

PDB ID 3zgf

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OCA

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