Cadherin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:53, 2 June 2024) (edit) (undo)
 
(29 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1q1p.png|left|200px|thumb|Crystal Structure of Cadherin, [[1q1p]]]]
+
<StructureSection load='2a4c' size='350' side='right' scene='41/417481/Cv/4' caption='Mouse cadherin-11 EC1 dimer (PDB code [[2a4c]])'>
-
{{STRUCTURE_1q1p| PDB=1q1p | SIZE=400| SCENE=Cadherin/Cv/1 |right|CAPTION=Epithelial cadherin complex with Ca+2 ions, [[1q1p]] }}
+
__TOC__
 +
== Function ==
 +
[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney). The CDH superfamily contains:<br />
 +
*'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
 +
*'''Desmogleins''' (Des-CDH) and '''desmocollin''' are CDH found in desmosomes.
 +
== Structural highlights ==
-
 
+
The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by <scene name='41/417481/Cv/5'>2 Trp residues</scene> docking into the hydrophobic pocket of the neighboring CDH molecule. <ref>PMID:16564015</ref>
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, ''i.e.'' the crystal structure of Cadherin ([[1q1p]]). Calcium ions is shown as a space filling objects.
+
== 3D Structures of Cadherin ==
== 3D Structures of Cadherin ==
 +
[[Cadherin 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
 
+
-
=== CDH1 ===
+
-
 
+
-
[[1q1p]] – mCDH1 - mouse<br />
+
-
[[3q2v]] – mCDH1 ectodomain<br />
+
-
[[3qrb]] – mCDH1+2
+
-
 
+
-
=== CDH5 ===
+
-
 
+
-
[[2koh]] – mCDH5+PAR3-PDZ3<br />
+
-
 
+
-
=== CDH6 ===
+
-
 
+
-
[[3lnd]] – mCDH6 EC12 (mutant)<br />
+
-
 
+
-
=== CDH8 ===
+
-
 
+
-
[[1zxk]] – mCDH8 EC1<br />
+
-
[[2a62]] - mCDH8 EC1+EC2+EC3<br />
+
-
 
+
-
=== CDH11 ===
+
-
 
+
-
[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
+
-
 
+
-
=== CDH20 ===
+
-
 
+
-
[[1zvn]] – cCDH20 EC1 – chicken<br />
+
-
 
+
-
=== CDH23 ===
+
-
 
+
-
[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
+
-
[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
+
-
[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
+
-
[[2wbx]] – mCDH23 EC1<br />
+
-
[[2wcp]] - mCDH23 EC2<br />
+
-
[[2wd0]] - mCDH23 EC1+EC2 (mutant)<br />
+
-
[[4apx]], [[4aq8]], [[4axw]] - mCDH23 EC1+EC2 + Pro-CDH15<br />
+
-
[[4aqa]], [[4aqe]] - mCDH23 EC1+EC2 (mutant) + Pro-CDH15
+
-
 
+
-
=== C-CDH “classical” ===
+
-
 
+
-
[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
+
-
[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
+
-
 
+
-
=== E-CDH epithelial ===
+
-
 
+
-
[[1ff5]] – mE-CDH double domain<br />
+
-
[[1edh]] - mE-CDH EC1+EC2+Ca<br />
+
-
[[3q2l]], [[3q2n]] - mE-CDH EC1+EC2 (mutant)<br />
+
-
[[1suh]] – mE-CDH N-terminal - NMR<br />
+
-
[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
+
-
[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
+
-
[[2qvf]] – mE-CDH1 CDH2<br />
+
-
[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
+
-
[[2o72]] - hE-CDH EC1+EC2<br />
+
-
[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
+
-
[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
+
-
[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
+
-
 
+
-
=== T-CDH membrane bound ===
+
-
 
+
-
[[3k5r]] – mT-CDH EC1+EC2<br />
+
-
[[3k5s]] - cT-CDH EC1+EC2 <br />
+
-
[[3k6d]] - XlT-CDH EC1 <br />
+
-
[[3k6f]] - mT-CDH EC1<br />
+
-
[[3k6i]] - cT-CDH EC1<br />
+
-
[[2v37]] – hT-CDH N-terminal - NMR<br />
+
-
 
+
-
=== N-CDH neuronal ===
+
-
 
+
-
[[1nch]], [[1nci]] – mN-CDH<br />
+
-
[[1ncg]] – mN-CDH (mutant)<br />
+
-
[[2qvi]] – mN-CDH EC12<br />
+
-
[[1ncj]] – mN-CDH two domains<br />
+
-
[[3q2w]] – mN-CDH ectodomain<br />
+
-
[[1op4]] - mN-CDH prodomain - NMR<br />
+
-
[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
+
-
[[3ubh]] - DmN-CDH EC1-4<br />
+
-
[[3ubg]] - DmN-CDH EC1-
+
-
 
+
-
===VE-CDH vascular epithelial===
+
-
 
+
-
[[3ppe]] – cVE-CDH EC1+EC2<br />
+
-
 
+
-
=== Protocadherin ===
+
-
 
+
-
[[2yst]] – hProt-CDH7 EC3 – NMR<br />
+
-
[[2ee0]] - hProt-CDH9 Ca domain – NMR<br />
+
-
[[1wyj]] - mProt-CDH β 14 - NMR<br />
+
-
[[1wuz]] - mProt-CDH4 EC1 – NMR
+
-
 
+
-
=== Desmoglein ===
+
-
 
+
-
[[2yqg]] – hDes-CDH EC1<br />
+
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Mouse cadherin-11 EC1 dimer (PDB code 2a4c)

Drag the structure with the mouse to rotate

References

  1. ↑ Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368
  2. ↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Cadherin"
Personal tools