Catenin

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<StructureSection load='2z6g' size='350' side='right' scene='41/417478/Cv/3' caption='Zebrafish β-catenin (PDB code [[2z6g]])'>
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{{STRUCTURE_2z6g| PDB=2z6g | SIZE=400| SCENE=Catenin/Cv/1 |right|CAPTION=Zebrafish β-Catenin, [[2z6g]] }}
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== Function ==
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<ref>PMID:17005550</ref><br />
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<br />
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* '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br />
* '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br />
* '''β-CTN''' is a subunit of the cadherin complex. It contains [[Armadillo repeats]] which are a pair of helices forming hairpin structure.<br />
* '''β-CTN''' is a subunit of the cadherin complex. It contains [[Armadillo repeats]] which are a pair of helices forming hairpin structure.<br />
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* '''δ-CTN''' is expressed in the brain and contains 10 armadillo repeats.<br />
* '''δ-CTN''' is expressed in the brain and contains 10 armadillo repeats.<br />
* '''p120 CTN''' is another member of the CTN family.<br />
* '''p120 CTN''' is another member of the CTN family.<br />
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The images at the left and at the right correspond to one representative Catenin, ''i.e.'' the crystal structure of full-length zebrafish β-catenin ([[2z6g]]).
 
== 3D Structures of Catenin ==
== 3D Structures of Catenin ==
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[[Catenin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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=== P120 CTN ===
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[[3l6x]], [[3l6y]] – p120 CTN (mutant) +E-CDH – human<br />
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=== α-CTN ===
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[[4k1n]] - mα-CTN - mouse<br />
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[[1l7c]], [[4k1o]] – mα-CTN C-terminal <br />
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[[4igg]] - hα-CTN<br />
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[[1h6g]] - hα-CTN M domain<br />
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[[1dov]] - mα-CTN dimerization domain<br />
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[[1dow]] - mα-CTN dimerization domain+ mβ-CTN chimera<br />
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[[4ehp]] - hα-CTN residues 277-382 + vinculin head domain<br />
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=== β-CTN ===
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[[3diw]] – mβ-CTN C-terminal+Tax interaction protein 1 <br />
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[[2z6g]] - β-CTN – zebrafish<br />
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[[4ev8]], [[4ev9]], [[4eva]], [[4evp]], [[4evt]] - mβ-CTN<br />
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[[2z6h]] - hβ-CTN C-terminal<br />
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[[2gl7]] - hβ-CTN (mutant)+TCF-4+B-cell lymphoma protein<br />
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[[3sl9]] - hβ-CTN +B-cell lymphoma protein 9<br />
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[[3sla]] - hβ-CTN repeats 1-4<br />
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[[3tx7]] - hβ-CTN + nuclear receptor LRH-1<br />
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[[2g57]] - β-CTN fragment – NMR<br />
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[[3bct]], [[2bct]] - mβ-CTN armadillo repeats<br />
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[[1v18]] - mβ-CTN armadillo repeats+apc protein<br />
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[[1t08]] - hβ-CTN armadillo repeats+apc protein+ hβ-CTN interacting protein<br />
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[[1th1]] - hβ-CTN armadillo repeats+apc protein<br />
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[[1qz7]] - hβ-CTN armadillo repeats+axis inhibition protein <br />
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[[1g3j]] - hβ-CTN armadillo repeats+TCF3-CBD<br />
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[[1p22]] - hβ-CTN +skp1+trcp1<br />
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[[1luj]] - hβ-CTN C-terminal+ hβ-CTN interacting protein<br />
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[[1jdh]], [[1jpw]] - hβ-CTN C-terminal+HTCF-4<br />
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[[4djs]] - hβ-CTN armadillo repeats + peptide inhibitor<br />
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[[1m1e]] - mβ-CTN armadillo repeats + mβ-CTN interacting protein<br />
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[[1jpp]] - mβ-CTN armadillo repeats+apc protein<br />
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[[1i7x]], [[1i7w]] - mβ-CTN armadillo repeats+E-CDH<br />
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[[3ouw]], [[3oux]] - mβ-CTN+lymphoid enhancer-binding factor 1
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=== γ-CTN ===
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[[3ifq]] – hγ-CTN+E-CDH EC1+EC2+EC3<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Zebrafish β-catenin (PDB code 2z6g)

Drag the structure with the mouse to rotate

References

  1. ↑ Weis WI, Nelson WJ. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem. 2006 Nov 24;281(47):35593-7. Epub 2006 Sep 27. PMID:17005550 doi:http://dx.doi.org/10.1074/jbc.R600027200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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