Diphtheria toxin repressor

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<StructureSection load='1c0w' size='350' side='right' caption='Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry [[1c0w]])' scene=''>
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<StructureSection load='1c0w' size='350' side='right' caption='Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry [[1c0w]])' scene='55/554905/Cv/1'>
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'''Diphtheria toxin repressor''' (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. DtxR structure contains a DNA-binding domain (DBD) containing the hlix-turn-helix motif at the N-terminal, an interface domain containing the metal-binding sites and a flexible C-terminal. The DtxR regulates the expression of high affinity iron uptake system.
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'''Diphtheria toxin repressor''' (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. The DtxR regulates the expression of high affinity iron uptake system. <ref>PMID:12675807</ref>
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== Structural highlights ==
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DtxR structure contains an <scene name='55/554905/Cv/7'>N-terminal domain</scene> which contains <scene name='55/554905/Cv/8'>DNA-binding domain (DBD) with a helix-turn-helix motif</scene>, dimerization and metal-binding residues. DtxR contains <scene name='55/554905/Cv/9'>2 metal binding sites</scene>.
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*<scene name='55/554905/Cv/10'>First metal binding site</scene>.
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*<scene name='55/554905/Cv/11'>Second metal binding site</scene>.
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A C-terminal domain folds into SH3-like conformation.<ref>PMID:10497029</ref>
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</StructureSection>
==3D structures of diphtheria toxin repressor==
==3D structures of diphtheria toxin repressor==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===DtxR===
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*DtxR
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[[1dpr]], [[1bi1]], [[1bi2]] – CdDtxR – ''Corynebacterium diphtheriae''<br />
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**[[1dpr]], [[1bi1]], [[1bi2]] – CdDtxR – ''Corynebacterium diphtheriae''<br />
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[[1g3s]], [[1g3t]], [[1p92]] – CdDtxR (mutant) <br />
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**[[1g3s]], [[1g3t]], [[1p92]] – CdDtxR (mutant) <br />
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[[1bym]], [[1qvp]], [[1qw1]] – CdDtxR C terminal - NMR<br />
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**[[1bym]], [[1qvp]], [[1qw1]] – CdDtxR C terminal - NMR<br />
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===DtxR complex with metal===
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*DtxR complex with metal
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[[2dtr]] – CdDtxR + Co<br />
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**[[2dtr]] – CdDtxR + Co<br />
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[[1bi3]], [[1bi0]] – CdDtxR + Zn<br />
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**[[1bi3]], [[1bi0]] – CdDtxR + Zn<br />
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[[1fwz]], [[1g3y]] – CdDtxR (mutant) + Zn<br />
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**[[1fwz]], [[1g3y]] – CdDtxR (mutant) + Zn<br />
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[[2tdx]], [[1xcv]], [[2qq9]], [[2qqa]], [[2qqb]], [[3glx]] – CdDtxR (mutant) + Ni <br />
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**[[2tdx]], [[1xcv]], [[2qq9]], [[2qqa]], [[2qqb]], [[3glx]] – CdDtxR (mutant) + Ni <br />
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[[1g3w]] – CdDtxR (mutant) + Cd<br />
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**[[1g3w]] – CdDtxR (mutant) + Cd<br />
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===DtxR complex with metal and DNA===
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*DtxR complex with metal and DNA
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[[1ddn]], [[1f5t]] – CdDtxR (mutant) + Ni + DNA<br />
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**[[1ddn]], [[1f5t]] – CdDtxR (mutant) + Ni + DNA<br />
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[[1c0w]] – CdDtxR + Co + DNA<br />
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**[[1c0w]] – CdDtxR + Co + DNA<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry 1c0w)

Drag the structure with the mouse to rotate

3D structures of diphtheria toxin repressor

Updated on 24-February-2019

References

  1. ↑ Guedon E, Helmann JD. Origins of metal ion selectivity in the DtxR/MntR family of metalloregulators. Mol Microbiol. 2003 Apr;48(2):495-506. PMID:12675807
  2. ↑ Pohl E, Holmes RK, Hol WG. Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain. J Mol Biol. 1999 Sep 24;292(3):653-67. PMID:10497029 doi:10.1006/jmbi.1999.3073

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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