Muconate cycloisomerase

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{{STRUCTURE_3fyy| PDB=3fyy | SIZE=400| SCENE= |right|CAPTION=Muconate cycloisomerase dimer complex with Mg+2 ion (green), [[3fyy]] }}
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<StructureSection load='3fyy' size='350' side='right' caption='Muconate cycloisomerase dimer complex with Mg+2 ion (green) (PDB entry [[3fyy]])' scene=''>
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'''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from cis, cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds.
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'''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from ''cis,cis''-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds<ref>PMID:9726873</ref>. MCI breaks down lignin-derived catechol and protocatechuate.
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*'''Chloromuconate cycloisomerase''' catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to ''cis,cis''-butadiene-1,2,4-tricarboxylate <ref>PMID:7305906</ref>.<br />
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*'''3-carboxy-''cis,cis''-muconate cycloisomerase''' catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-''cis,cis''-muconate<ref>PMID:5916392</ref>.<br />
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</StructureSection>
== 3D Structures of muconate cycloisomerase ==
== 3D Structures of muconate cycloisomerase ==
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===Cloro-MCI===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[2chr]] – MCI – ''Cupriavidsua necator''<br />
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*'''Chloro-MCI'''
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[[1nu5]] - MCI – ''Pseudomonas''
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===cis, cis-MCI===
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**[[2chr]] – MCI – ''Cupriavidsua necator''<br />
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**[[1nu5]] - MCI – ''Pseudomonas''<br />
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**[[4m0x]] – MCI – ''Rhodococcus opacus''<br />
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[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br />
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*'''MCI'''
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[[3muc]], [[2muc]], [[1f9c]] – PbMCI (mutant) <br />
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[[3fyy]] – OiMCI – ''Oceanobacillus iheyensis''<br />
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[[3i4k]] – MCI – ''Corynebacterium glutamicum''<br />
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[[3i6e]] – MCI – ''Ruegeria pomeroyi''<br />
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[[3i6t]] – MCI – ''Jannaschia''<br />
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[[3my9]] – MCI – ''Azorhizobium caulinodans''<br />
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[[2zad]] – TmMCI – ''Thermotoga maritima''<br />
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[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br />
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[[3dg3]] – MsMCI - ''Mycobacterium smegmatis''
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===cis, cis-MCI complexes===
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**[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br />
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**[[3muc]], [[2muc]], [[1f9c]] – PbMCI (mutant) <br />
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**[[2oqy]], [[3fyy]] – OiMCI – ''Oceanobacillus iheyensis''<br />
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**[[3i4k]] – MCI – ''Corynebacterium glutamicum''<br />
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**[[3i6e]] – MCI – ''Ruegeria pomeroyi''<br />
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**[[3i6t]] – MCI – ''Jannaschia''<br />
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**[[3my9]] – MCI – ''Azorhizobium caulinodans''<br />
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**[[2zad]] – TmMCI – ''Thermotoga maritima''<br />
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**[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br />
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**[[3dg3]] – MsMCI - ''Mycobacterium smegmatis''<br />
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**[[3fcp]] – MCI – ''Klebsiella pneumoniae''<br />
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[[3es7]], [[3es8]] – OiMCI + Mg + malate<br />
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*MCI complexes
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[[3gd6]] – OiMCI + phosphate<br />
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[[3hpf]] – OiMCI (mutant) + Mg + galactarate<br />
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[[3dg6]], [[3dg7]] – MsMCI + muconolactone<br />
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[[3dgb]], [[3fj4]] - PfMCI + muconolactone
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===3-carboxy-cis, cis-MCI===
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**[[3es7]], [[3es8]] – OiMCI + Mg + malate<br />
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**[[3gd6]] – OiMCI + phosphate<br />
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**[[3hpf]] – OiMCI (mutant) + Mg + galactarate<br />
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**[[3dg6]], [[3dg7]] – MsMCI + muconolactone<br />
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**[[3dgb]], [[3fj4]] - PfMCI + muconolactone
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[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br />
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*'''3-carboxy-cis, cis-MCI'''
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[[1re5]] - PbMCI
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===Dipeptide epimerase===
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**[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br />
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**[[1re5]] - PbMCI <br />
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**[[1jof]] – MCI – ''Neurospora crassa''<br />
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**[[2fel]], [[2fen]] – MCI – ''Agrobacterium tumefaciens''<br />
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[[3iji]], [[3ijl]], [[3ijq]]– MCI + dipeptide – ''Bacterioides thetaiotaomicron''<br />
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*'''Dipeptide epimerase'''
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[[3deq]], [[3der]], [[3des]] – TmMCI + dipeptide<br />
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[[3dfy]] – TmMCI<br />
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[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br />
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[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus''
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**[[3iji]], [[3ijl]], [[3ijq]]– MCI + dipeptide – ''Bacterioides thetaiotaomicron''<br />
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**[[3deq]], [[3der]], [[3des]] – TmMCI + dipeptide<br />
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**[[3dfy]] – TmMCI<br />
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**[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br />
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**[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus''<br />
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**[[3jva]] – EfMCI + Mg – ''Enterococcus faecalis''<br />
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**[[3jw7]], [[3jzu]], [[3k1g]], [[3kum]] – EfMCI + Mg + dipeptide<br />
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Muconate cycloisomerase dimer complex with Mg+2 ion (green) (PDB entry 3fyy)

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3D Structures of muconate cycloisomerase

Updated on 10-November-2021

References

  1. ↑ Vollmer MD, Hoier H, Hecht HJ, Schell U, Groning J, Goldman A, Schlomann M. Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants. Appl Environ Microbiol. 1998 Sep;64(9):3290-9. PMID:9726873
  2. ↑ Schmidt E, Knackmuss HJ. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem J. 1980 Oct 15;192(1):339-47. PMID:7305906
  3. ↑ Ornston LN. The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway. J Biol Chem. 1966 Aug 25;241(16):3787-94. PMID:5916392

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Michal Harel

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