Sentrin-specific protease

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<StructureSection load='2iy0' size='350' side='right' caption='Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry [[2iy0]])' scene=''>
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<StructureSection load='2iy0' size='350' side='right' caption='Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry [[2iy0]])' scene='' pspeed='8'>
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'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide.
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'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide<ref>PMID:24586832</ref>.<br />
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*'''SENP2''' localised in cytoplasmic vesicles and nuclear body.
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*'''SENP7''' localised in breast epithelium.
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<scene name='56/568937/Cv/1'>human Senp1 catalytic domain complex with SUMO1 and RanGAP C terminal</scene> (PDB entry [[2iy0]]).
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</StructureSection>
==3D structures of sentrin-specific protease==
==3D structures of sentrin-specific protease==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Senp1===
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*Sentrin-specific protease 1
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[[2ckg]], [[2iyc]] – hSenp1 C terminal – human<br />
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**[[2ckg]], [[2iyc]] – hSenp1 catalytic domain – human<br />
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[[2xph]], [[2xre]] – hSenp1 C terminal + Co<br />
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**[[2xph]], [[2xre]] – hSenp1 catalytic domain + Co<br />
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[[2ckh]], [[2iyd]] – hSenp1 C terminal + SUMO2<br />
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**[[2iy1]], [[2g4d]] – hSenp1 catalytic domain (mutant) + SUMO1<br />
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[[2iy1]], [[2g4d]] – hSenp1 C terminal (mutant) + SUMO1<br />
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**[[2ckh]], [[2iyd]] – hSenp1 catalytic domain + SUMO2<br />
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[[2iy0]] – hSenp1 C terminal + SUMO1 + RanGAP C terminal<br />
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**[[6nnq]] – hSenp1 catalytic domain + SUMO3<br />
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**[[2iy0]] – hSenp1 catalytic domain + SUMO1 + RanGAP C terminal<br />
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===Senp2===
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*Sentrin-specific protease 2
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[[1tgz]] – hSenp2 catalytic domain + SUMO1<br />
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**[[1th0]] – hSenp2 catalytic domain <br />
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[[1th0]] – hSenp2 catalytic domain <br />
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**[[1tgz]] – hSenp2 catalytic domain + SUMO1<br />
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[[2io0]] – hSenp2 catalytic domain (mutant) + SUMO1 precursor<br />
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**[[2io0]], [[5aek]] – hSenp2 catalytic domain (mutant) + SUMO1 precursor<br />
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[[3zo5]] - hSenp2 catalytic domain (mutant) + SUMO2 precursor<br />
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**[[3zo5]] - hSenp2 catalytic domain (mutant) + SUMO2 precursor<br />
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[[2io1]] – hSenp2 catalytic domain (mutant) + SUMO3 precursor<br />
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**[[2io1]] – hSenp2 catalytic domain (mutant) + SUMO3 precursor<br />
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[[2io3]] – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal<br />
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**[[2io3]] – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal<br />
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[[2io2]] – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal<br />
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**[[2io2]] – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal<br />
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===Senp7===
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*Sentrin-specific protease 7
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[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
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**[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
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**[[7r2e]] – hSenp7 catalytic domain + SUMO2<br />
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===Senp8===
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*Sentrin-specific protease 8
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[[1xt9]], [[2bkr]] – hSenp8 + Nedd8<br />
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**[[1xt9]], [[2bkr]] – hSenp8 + Nedd8<br />
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[[2bkq]] – hSenp8 <br />
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**[[2bkq]] – hSenp8 <br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0)

Drag the structure with the mouse to rotate

3D structures of sentrin-specific protease

Updated on 11-August-2024

References

  1. ↑ Lee WP, Jena S, Doherty D, Ventakesh J, Schimdt J, Furmick J, Widener T, Lemau J, Jurutka PW, Thompson PD. Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling. PLoS One. 2014 Feb 20;9(2):e89506. doi: 10.1371/journal.pone.0089506. eCollection, 2014. PMID:24586832 doi:http://dx.doi.org/10.1371/journal.pone.0089506

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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