This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4kh5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:58, 30 November 2022) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Toxoplasma gondii NTPDase1 C258S/C268S in complex with Mg and AMPNP==
==Toxoplasma gondii NTPDase1 C258S/C268S in complex with Mg and AMPNP==
-
<StructureSection load='4kh5' size='340' side='right' caption='[[4kh5]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+
<StructureSection load='4kh5' size='340' side='right'caption='[[4kh5]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4kh5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KH5 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4kh5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KH5 FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU1:5-O-[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]ADENOSINE'>AU1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU1:5-O-[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]ADENOSINE'>AU1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a57|4a57]], [[4a59|4a59]], [[4a5a|4a5a]], [[4a5b|4a5b]], [[4jep|4jep]], [[4kh4|4kh4]], [[4kh6|4kh6]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kh5 OCA], [https://pdbe.org/4kh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kh5 RCSB], [https://www.ebi.ac.uk/pdbsum/4kh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kh5 ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NTP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
+
</table>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphatase Nucleoside-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.15 3.6.1.15] </span></td></tr>
+
== Function ==
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kh5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kh5 RCSB], [http://www.ebi.ac.uk/pdbsum/4kh5 PDBsum]</span></td></tr>
+
[https://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
-
<table>
+
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4kh5" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Ectonucleoside triphosphate diphosphohydrolase|Ectonucleoside triphosphate diphosphohydrolase]]
*[[Ectonucleoside triphosphate diphosphohydrolase|Ectonucleoside triphosphate diphosphohydrolase]]
 +
*[[Nucleoside triphosphatase|Nucleoside triphosphatase]]
 +
*[[Sandbox 30008|Sandbox 30008]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Nucleoside-triphosphatase]]
+
[[Category: Large Structures]]
-
[[Category: Toxgo]]
+
[[Category: Toxoplasma gondii]]
-
[[Category: Krug, U.]]
+
[[Category: Krug U]]
-
[[Category: Strater, N.]]
+
[[Category: Strater N]]
-
[[Category: Totzauer, R.]]
+
[[Category: Totzauer R]]
-
[[Category: Actin-like fold]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Ntpdase]]
+

Current revision

Toxoplasma gondii NTPDase1 C258S/C268S in complex with Mg and AMPNP

PDB ID 4kh5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kh5"
Personal tools