4r2y
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4r2y is ON HOLD Authors: Brown, N.G., Watson, E.R., Weissmann, F., Jarvis, M.A., Vanderlinden, R., Grace, C.R.R., Frye, J.J., Dube, P., Qiao, R., Pe...) |
|||
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of APC11 RING domain== | |
| - | + | <StructureSection load='4r2y' size='340' side='right'caption='[[4r2y]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r2y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R2Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.755Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r2y OCA], [https://pdbe.org/4r2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r2y RCSB], [https://www.ebi.ac.uk/pdbsum/4r2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r2y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APC11_HUMAN APC11_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alsharif O]] | ||
| + | [[Category: Bao J]] | ||
| + | [[Category: Brown NG]] | ||
| + | [[Category: Cho SE]] | ||
| + | [[Category: Dube P]] | ||
| + | [[Category: Frye JJ]] | ||
| + | [[Category: Grace CRR]] | ||
| + | [[Category: Jarvis MA]] | ||
| + | [[Category: Kurinov I]] | ||
| + | [[Category: Nourse A]] | ||
| + | [[Category: Peters JM]] | ||
| + | [[Category: Petzold G]] | ||
| + | [[Category: Qiao R]] | ||
| + | [[Category: Schulman BA]] | ||
| + | [[Category: Stark H]] | ||
| + | [[Category: Vanderlinden R]] | ||
| + | [[Category: Watson ER]] | ||
| + | [[Category: Weissmann F]] | ||
| + | [[Category: Zheng J]] | ||
Current revision
Crystal structure of APC11 RING domain
| |||||||||||
Categories: Homo sapiens | Large Structures | Alsharif O | Bao J | Brown NG | Cho SE | Dube P | Frye JJ | Grace CRR | Jarvis MA | Kurinov I | Nourse A | Peters JM | Petzold G | Qiao R | Schulman BA | Stark H | Vanderlinden R | Watson ER | Weissmann F | Zheng J
