4uwh

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'''Unreleased structure'''
 
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The entry 4uwh is ON HOLD until Paper Publication
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==Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors==
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<StructureSection load='4uwh' size='340' side='right'caption='[[4uwh]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4uwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UWH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JXM:(8S)-9-[(2R)-2-HYDROXY-2-PHENYLETHYL]-2-(MORPHOLIN-4-YL)-8-(TRIFLUOROMETHYL)-6,7,8,9-TETRAHYDRO-4H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>JXM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwh OCA], [https://pdbe.org/4uwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uwh RCSB], [https://www.ebi.ac.uk/pdbsum/4uwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
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Authors: Pasquier, B., El-Ahmad, Y., Filoche-Romme, B., Dureuil, C., Fassy, F., Abecassis, P.Y., Mathieu, M., Bertrand, T., Benard, T., Barriere, C., ElBatti, S., Letallec, J.P., Sonnefraud, V., Brollo, M., Delbarre, L., Loyau, V., Pilorge, F., Bertin, L., Richepin, P., Arigon, J., Labrosse, J.R., Clement, J., Durand, F., Combet, R., Perraut, P., Leroy, V., Gay, F., Lefrancois, D., Bretin, F., Marquette, J.P., Michot, N., Caron, A., Castell, C., Schio, L., McCort, G., Goulaouic, H., Garcia-Echeverria, C.
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==See Also==
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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Description: Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Abecassis PY]]
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[[Category: Arigon J]]
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[[Category: Barriere C]]
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[[Category: Benard T]]
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[[Category: Bertin L]]
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[[Category: Bertrand T]]
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[[Category: Bretin F]]
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[[Category: Brollo M]]
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[[Category: Caron A]]
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[[Category: Castell C]]
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[[Category: Clement J]]
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[[Category: Combet R]]
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[[Category: Delbarre L]]
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[[Category: Durand F]]
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[[Category: Dureuil C]]
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[[Category: El-Ahmad Y]]
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[[Category: ElBatti S]]
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[[Category: Fassy F]]
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[[Category: Filoche-Romme B]]
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[[Category: Garcia-Echeverria C]]
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[[Category: Gay F]]
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[[Category: Goulaouic H]]
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[[Category: Labrosse JR]]
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[[Category: Lefrancois D]]
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[[Category: Leroy V]]
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[[Category: Letallec JP]]
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[[Category: Loyau V]]
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[[Category: Marquette JP]]
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[[Category: Mathieu M]]
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[[Category: McCort G]]
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[[Category: Michot N]]
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[[Category: Pasquier B]]
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[[Category: Perraut P]]
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[[Category: Pilorge F]]
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[[Category: Richepin P]]
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[[Category: Ronan B]]
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[[Category: Schio L]]
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[[Category: Sonnefraud V]]

Current revision

Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

PDB ID 4uwh

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