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4tyo

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==PPIase in complex with a non-phosphate small molecule inhibitor.==
==PPIase in complex with a non-phosphate small molecule inhibitor.==
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<StructureSection load='4tyo' size='340' side='right' caption='[[4tyo]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='4tyo' size='340' side='right'caption='[[4tyo]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tyo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39X:3-(6-FLUORO-1H-BENZIMIDAZOL-2-YL)-N-(NAPHTHALEN-2-YLCARBONYL)-D-ALANINE'>39X</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i6c|3i6c]], [[3jyj|3jyj]], [[3ikg|3ikg]], [[3ik8|3ik8]], [[3ikd|3ikd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=39X:3-(6-FLUORO-1H-BENZIMIDAZOL-2-YL)-N-(NAPHTHALEN-2-YLCARBONYL)-D-ALANINE'>39X</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyo OCA], [https://pdbe.org/4tyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyo RCSB], [https://www.ebi.ac.uk/pdbsum/4tyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyo ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyo RCSB], [http://www.ebi.ac.uk/pdbsum/4tyo PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tyo" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Homo sapiens]]
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[[Category: Ferre, R A.]]
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[[Category: Large Structures]]
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[[Category: Greasley, S E.]]
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[[Category: Ferre RA]]
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[[Category: Cell cycle]]
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[[Category: Greasley SE]]
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[[Category: Isomerase]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Nucleus]]
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[[Category: Peptidyl-prolyl cis-trans isomerase]]
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[[Category: Phosphoprotein]]
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[[Category: Ppiase]]
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[[Category: Rotamase]]
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[[Category: Sbdd]]
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[[Category: Small molecule]]
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Current revision

PPIase in complex with a non-phosphate small molecule inhibitor.

PDB ID 4tyo

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