4n14

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==Crystal structure of Cdc20 and apcin complex==
==Crystal structure of Cdc20 and apcin complex==
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<StructureSection load='4n14' size='340' side='right' caption='[[4n14]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4n14' size='340' side='right'caption='[[4n14]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N14 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N14 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WR7:2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL+[(1R)-2,2,2-TRICHLORO-1-(PYRIMIDIN-2-YLAMINO)ETHYL]CARBAMATE'>WR7</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gga|4gga]], [[4ggc|4ggc]], [[4ggd|4ggd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WR7:2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL+[(1R)-2,2,2-TRICHLORO-1-(PYRIMIDIN-2-YLAMINO)ETHYL]CARBAMATE'>WR7</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n14 RCSB], [http://www.ebi.ac.uk/pdbsum/4n14 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n14 OCA], [https://pdbe.org/4n14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n14 RCSB], [https://www.ebi.ac.uk/pdbsum/4n14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n14 ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/CDC20_HUMAN CDC20_HUMAN] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<ref>PMID:9811605</ref> <ref>PMID:9734353</ref> <ref>PMID:9637688</ref>
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Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and degradation of securin and cyclin B, thus promoting the onset of anaphase and mitotic exit. APC/C(Cdc20) is temporally and spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including the spindle checkpoint and the cytostatic factor (CSF). Therefore, Cdc20 serves as an integrator of multiple intracellular signaling cascades that regulate progression through mitosis. This review summarizes recent progress toward the understanding of the functions of Cdc20, the mechanisms by which it activates APC/C, and its regulation by phosphorylation and by association with its binding proteins.
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Cdc20: a WD40 activator for a cell cycle degradation machine.,Yu H Mol Cell. 2007 Jul 6;27(1):3-16. PMID:17612486<ref>PMID:17612486</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Luo, X.]]
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[[Category: Homo sapiens]]
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[[Category: Tian, W.]]
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[[Category: Large Structures]]
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[[Category: Yu, H.]]
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[[Category: Luo X]]
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[[Category: Cell cycle]]
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[[Category: Tian W]]
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[[Category: Cell cycle-cell cycle inhibitor complex]]
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[[Category: Yu H]]
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[[Category: Mitosis]]
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[[Category: Securin]]
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[[Category: Ubiquitination]]
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[[Category: Wd40]]
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Current revision

Crystal structure of Cdc20 and apcin complex

PDB ID 4n14

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