B-cell lymphoma protein

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[[Image:Bcl-2_3D.jpg|left|200px]] [[Bcl-2]] family are pro-survival proteins. The name is derived from B-cell lymphoma 2.
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<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
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'''Bcl-xL''' known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an induced myeloid cell leukemia differentiation protein. '''Bcl-2-L-7''' is called '''Bak''' for Bcl-2 homologous antagonist/killer.
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[[Image:Bcl-2_3D.jpg|left|200px]]
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'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.
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*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.
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*'''Bak''' or '''Bcl-2-like-7''' or '''Bcl-2 homologous antagonist/killer''' and '''Bax''' or '''Bcl-2-like-4''' promote apoptosis
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*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.
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*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.
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*'''Bcl-2-like-11''' is called '''Bim'''.
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'''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.
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For '''Bcl-6''' see also [[BCL6 (Hebrew)]]
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==Overview==
==Overview==
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<applet load='1g5m' size='500' frame='true' align='right' caption='NMR structure of bcl-2 [[1g5m]]'/>
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Bcl-2 is a family of genes and proteins that govern the mitochondrial membrane permeabilization (MMP). Bcl-2 derives its name from B-cell lymphoma 2 which came from being the second member of a range of proteins initially described as a reciprocal gene translocation in chromosomes 14 and 18 in follicular lymphomas. The genes and proteins can be either pro-apoptotic (Bax, BAD, Bak and Bok) or anti-apoptotic (Bcl-2, Bcl-xL, and Bcl-w). These genes interact with the Bcl-2 protein structure, which result in either a pro- or anti-apoptosis function. The sites on Bcl-2 where the genes interact, have been characterized by Dr. JC Reed et al[2]. These domains are <scene name='Bcl-2/Bh1/3'>BH1 (residues 136-155)</scene>, <scene name='Bcl-2/Bh2/1'>BH2 (187-202)</scene>, <scene name='Bcl-2/Bh3/2'>BH3 (93-107)</scene> and <scene name='Bcl-2/Bh4/1'>BH4 (10-30)</scene>. Dr. Reed found that any deletion of these domains, abolishes Bcl-2's ability to suppress cell death.
Bcl-2 is a family of genes and proteins that govern the mitochondrial membrane permeabilization (MMP). Bcl-2 derives its name from B-cell lymphoma 2 which came from being the second member of a range of proteins initially described as a reciprocal gene translocation in chromosomes 14 and 18 in follicular lymphomas. The genes and proteins can be either pro-apoptotic (Bax, BAD, Bak and Bok) or anti-apoptotic (Bcl-2, Bcl-xL, and Bcl-w). These genes interact with the Bcl-2 protein structure, which result in either a pro- or anti-apoptosis function. The sites on Bcl-2 where the genes interact, have been characterized by Dr. JC Reed et al[2]. These domains are <scene name='Bcl-2/Bh1/3'>BH1 (residues 136-155)</scene>, <scene name='Bcl-2/Bh2/1'>BH2 (187-202)</scene>, <scene name='Bcl-2/Bh3/2'>BH3 (93-107)</scene> and <scene name='Bcl-2/Bh4/1'>BH4 (10-30)</scene>. Dr. Reed found that any deletion of these domains, abolishes Bcl-2's ability to suppress cell death.
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==3D structures of Bcl-2==
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==3D structures of B-cell lymphoma proteins==
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[[B-cell lymphoma proteins 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===Bcl-xL===
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[[1maz]], [[1r2d]], [[2b48]] – hBcl-xL – human<br />
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[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
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[[1lxl]] - hBcl-xL residues 1-209 - NMR<br />
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[[3pl7]] - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain<br />
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[[3fdl]] - hBcl-xL + BH3 peptide<br />
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[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
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[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
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[[1ysg]] - hBcl-xL + inhibitor<br />
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[[2w3l]] – hBcl-xL + quinoline derivative<br />
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[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]] - hBcl-xL + sulfonamide derivative – NMR<br />
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[[3qkd]] - hBcl-xL + sulfonamide derivative<br />
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[[2yxj]] - hBcl-xL + antagonist<br />
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[[2pon]] - hBcl-xL + Beclin-1<br />
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[[2p1l]] - hBcl-xL (mutant) + Beclin-1<br />
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[[1g5j]] - hBcl-xL residues 1-209 + BAD peptide (mutant)<br />
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[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
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[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant)<br />
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[[2bzw]] - mBcl-xL residues 1-211 + BAD<br />
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[[1pq1]] - mBcl-xL residues 1-196 + Bcl-2-like protein 11<br />
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[[1af3]] - rBcl-xL soluble domain<br />
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[[1bxl]] - Bcl-xL + Bak peptide – Escherichia coli – NMR<br />
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===Bcl-2===
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[[1gjh]], [[1g5m]] – hBcl-2<br />
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[[4aq3]], [[4man]] – hBcl-2 + inhibitor<br />
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[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
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[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator BAX BH3 domain<br />
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[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative - NMR<br />
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[[2kua]] – mBcl-2-L-10<br />
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[[3io8]] - hBcl-2-L-1 + hBcl-2-L-11 BH3 peptide (mutant)<br />
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[[3i1h]] - hBcl-2-L-5 + hBcl-2-L-7<br />
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[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBcl-2-L-7<br />
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[[3qbr]] - hBcl-2-L-7 + sjA<br />
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[[2xpx]] - hBcl-2-L-7 fragment + BHRF1<br />
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[[2vm6]] – hBcl-2A1 residues 1-149 + hBcl-2-L-11 peptide<br />
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[[2nl9]] – hBcl-2-L-11 + Mcl-1<br />
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===Bcl-w===
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[[1o0l]], [[1mk3]] – hBcl-w (mutant)<br />
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[[1zy3]] - hBcl-w (mutant) + BH3 peptide<br />
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===Mcl-1===
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[[2nla]] – rMcl-1 fragment + NoxaB BH3<br />
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[[1wsx]] – mMcl-1 residues 152-308<br />
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[[2jm6]], [[2rod]] – mMcl-1 fragment + NoxaB fragment – NMR<br />
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[[2roc]] - mMcl-1 fragment + Puma<br />
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[[3kz0]] - hMcl-1 + peptide MB7<br />
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[[3mk8]] - hMcl-1 fragment<br />
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[[2mhs]] - hMcl-1 fragment (mutant)<br />
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[[3pk1]] – hMcl-1 fragment + hBcl-2-L-4 BH3 domain<br />
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[[3kj0]], [[3kj1]], [[3kj2]], [[3io9]] - hMcl-1 fragment + hBcl-2-L-11 BH3 domain (mutant)<br />
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[[3d7v]], [[2pqk]] - hMcl-1 fragment + hBcl-2-L-11 BIM BH3<br />
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[[2kbw]] - hMcl-1 fragment + BID BH3 peptide – NMR<br />
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[[3wix]], [[3wiy]], [[4oq5]], 4oq6]] - hMcl-1 fragment + inhibitor<br />
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[[4bpj]] - hMcl-1 fragment + BH3 peptide <br />
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===M11===
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[[2o42]], [[2jbx]] – MvM11L – Myxoma virus<br />
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[[2jby]] – MvM11L + Bcl-2 homologous antagonis <br />
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[[3dvu]], [[3bl2]] – M11 + Beclin-1 – Murid herpesvirus<br />
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===N1L===
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</StructureSection>
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[[2i39]] – VvN1L – Vaccinia virus<br />
 
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[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
 
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==References==
==References==

Current revision

NMR structure of bcl-2 1g5m

Drag the structure with the mouse to rotate

References

1. Mee Young Hong; Chapkin, Robert S.; Davidson, Laurie A.; Turner, Nancy D.; Morris, Jeffrey S.; Carroll, Raymond J.; Lupton, Joanne R.. Nutrition & Cancer, 2003, Vol. 46 Issue 1, p44-44, 8p; DOI: NO_DOI; (AN 10719727)

2. Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG, Advances In Experimental Medicine And Biology, ISSN: 0065-2598, 1996; Vol. 406, pp. 99-112; PMID: 8910675

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