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4oji

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==Crystal Structure of Twister Ribozyme==
==Crystal Structure of Twister Ribozyme==
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<StructureSection load='4oji' size='340' side='right' caption='[[4oji]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4oji' size='340' side='right'caption='[[4oji]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oji]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OJI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oji]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OJI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oji RCSB], [http://www.ebi.ac.uk/pdbsum/4oji PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oji OCA], [https://pdbe.org/4oji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oji RCSB], [https://www.ebi.ac.uk/pdbsum/4oji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oji ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present a crystal structure at 2.3-A resolution of the recently described nucleolytic ribozyme twister. The RNA adopts a previously uncharacterized compact fold based on a double-pseudoknot structure, with the active site at its center. Eight highly conserved nucleobases stabilize the core of the ribozyme through the formation of one Watson-Crick and three noncanonical base pairs, and the highly conserved adenine 3' of the scissile phosphate is bound in the major groove of an adjacent pseudoknot. A strongly conserved guanine nucleobase directs its Watson-Crick edge toward the scissile phosphate in the crystal structure, and mechanistic evidence supports a role for this guanine as either a general base or acid in a concerted, general acid-base-catalyzed cleavage reaction.
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Crystal structure and mechanistic investigation of the twister ribozyme.,Liu Y, Wilson TJ, McPhee SA, Lilley DM Nat Chem Biol. 2014 Sep;10(9):739-44. doi: 10.1038/nchembio.1587. Epub 2014 Jul, 20. PMID:25038788<ref>PMID:25038788</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lilley, D M.J.]]
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[[Category: Large Structures]]
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[[Category: Liu, Y.]]
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[[Category: Lilley DMJ]]
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[[Category: McPhee, S A.]]
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[[Category: Liu Y]]
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[[Category: Wilson, T J.]]
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[[Category: McPhee SA]]
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[[Category: Pseudoknot]]
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[[Category: Wilson TJ]]
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[[Category: Rna]]
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[[Category: Self-cleavage]]
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Current revision

Crystal Structure of Twister Ribozyme

PDB ID 4oji

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