4r3m

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'''Unreleased structure'''
 
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The entry 4r3m is ON HOLD
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==Crystal structure of Human Hsp90 with JR9==
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<StructureSection load='4r3m' size='340' side='right'caption='[[4r3m]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JR9:N~3~-BENZYL-2-[(6-BROMO-1,3-BENZODIOXOL-5-YL)METHYL]IMIDAZO[1,2-A]PYRAZINE-3,8-DIAMINE'>JR9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3m OCA], [https://pdbe.org/4r3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3m RCSB], [https://www.ebi.ac.uk/pdbsum/4r3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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Authors: Jian Li, Min Yang, Jing Ren, Bing Xiong, Jianhua He
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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Description: Crystal structure of Human Hsp90 with JR9
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: He J]]
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[[Category: Li J]]
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[[Category: Ren J]]
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[[Category: Xiong B]]
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[[Category: Yang M]]

Current revision

Crystal structure of Human Hsp90 with JR9

PDB ID 4r3m

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