4r4q

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(New page: '''Unreleased structure''' The entry 4r4q is ON HOLD Authors: Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M.,...)
Current revision (12:50, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4r4q is ON HOLD
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==Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid==
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<StructureSection load='4r4q' size='340' side='right'caption='[[4r4q]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R4Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HZ:5-[4-({ACETYL[4-(5-CARBOXYFURAN-2-YL)BENZYL]AMINO}METHYL)PHENYL]-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>3HZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r4q OCA], [https://pdbe.org/4r4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r4q RCSB], [https://www.ebi.ac.uk/pdbsum/4r4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r4q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
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Authors: Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
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==See Also==
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
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Description: Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chazin WJ]]
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[[Category: Feldkamp MD]]
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[[Category: Fesik SW]]
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[[Category: Frank AO]]
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[[Category: Kennedy JP]]
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[[Category: Patrone JD]]
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[[Category: Pelz NF]]
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[[Category: Rossanese OW]]
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[[Category: Sousa-Fagundes EM]]
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[[Category: Vangamudi B]]
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[[Category: Waterson AG]]

Current revision

Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

PDB ID 4r4q

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OCA

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