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4nk7

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==Crystal Structure of the D. melanogaster Plk4 cryptic polo box (CPB)==
==Crystal Structure of the D. melanogaster Plk4 cryptic polo box (CPB)==
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<StructureSection load='4nk7' size='340' side='right' caption='[[4nk7]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
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<StructureSection load='4nk7' size='340' side='right'caption='[[4nk7]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nk7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NK7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nk7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NK7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g7n|4g7n]], [[4nkb|4nkb]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.233&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk7 OCA], [https://pdbe.org/4nk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4nk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nk7 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nk7 RCSB], [http://www.ebi.ac.uk/pdbsum/4nk7 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLK4_DROME PLK4_DROME] Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers.<ref>PMID:16326102</ref> <ref>PMID:17463247</ref> <ref>PMID:18555779</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nk7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Polo kinase]]
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[[Category: Drosophila melanogaster]]
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[[Category: Dong, G.]]
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[[Category: Large Structures]]
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[[Category: Lesigang, J.]]
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[[Category: Dong G]]
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[[Category: Asterless n-terminus]]
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[[Category: Lesigang J]]
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[[Category: Centrosome]]
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[[Category: Cryptic polo box]]
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[[Category: Plk4 targeting]]
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[[Category: Rocentriole]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the D. melanogaster Plk4 cryptic polo box (CPB)

PDB ID 4nk7

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