1dxz

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[[Image:1dxz.gif|left|200px]]
 
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{{Structure
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==M2 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 20 STRUCTURES==
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|PDB= 1dxz |SIZE=350|CAPTION= <scene name='initialview01'>1dxz</scene>
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<StructureSection load='1dxz' size='340' side='right'caption='[[1dxz]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
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<table><tr><td colspan='2'>[[1dxz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxz OCA], [https://pdbe.org/1dxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxz RCSB], [https://www.ebi.ac.uk/pdbsum/1dxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxz ProSAT]</span></td></tr>
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</table>
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'''M2 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 20 STRUCTURES'''
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== Function ==
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[https://www.uniprot.org/uniprot/ACHA_TETCF ACHA_TETCF] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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A synthetic peptide corresponding to the transmembrane segment M2 (residues 236-267) of the alpha-subunit of the nicotinic acetylcholine receptor from Torpedo californica has been studied by two dimensional 1H-NMR spectroscopy in a chloroform-methanol (1:1) mixture containing 0.1 M LiClO4. Reconstruction of the spatial structure of M2 from the NMR data resulted in an alpha-helix formed by residues 241-263. Distribution of the molecular hydrophobicity potential on the helix surface is very similar to that in five-helix bundles of proteins with a known three dimensional structure: two hydrophilic bands located on the opposite helix sides separated by strong hydrophobic zones.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxz_consurf.spt"</scriptWhenChecked>
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1DXZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXZ OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Spatial structure of the M2 transmembrane segment of the nicotinic acetylcholine receptor alpha-subunit., Pashkov VS, Maslennikov IV, Tchikin LD, Efremov RG, Ivanov VT, Arseniev AS, FEBS Lett. 1999 Aug 20;457(1):117-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10486576 10486576]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dxz ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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[[Category: Torpedo californica]]
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__TOC__
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[[Category: Arseniev, A S.]]
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</StructureSection>
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[[Category: Efremov, R G.]]
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[[Category: Large Structures]]
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[[Category: Ivanov, V T.]]
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[[Category: Tetronarce californica]]
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[[Category: Maslennikov, I V.]]
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[[Category: Arseniev AS]]
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[[Category: Pashkov, V S.]]
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[[Category: Efremov RG]]
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[[Category: Tchikin, L D.]]
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[[Category: Ivanov VT]]
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[[Category: NH2]]
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[[Category: Maslennikov IV]]
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[[Category: ion-channel]]
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[[Category: Pashkov VS]]
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[[Category: m2]]
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[[Category: Tchikin LD]]
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[[Category: nicotinic acetylcholine receptor]]
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[[Category: transmembrane segment]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:46:15 2008''
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Current revision

M2 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 20 STRUCTURES

PDB ID 1dxz

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