4r29
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of bacterial cysteine methyltransferase effector NleE== | |
| - | + | <StructureSection load='4r29' size='340' side='right'caption='[[4r29]], [[Resolution|resolution]] 2.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R29 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r29 OCA], [https://pdbe.org/4r29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r29 RCSB], [https://www.ebi.ac.uk/pdbsum/4r29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r29 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NLEE_ECO57 NLEE_ECO57] Cysteine methyltransferase effector that inhibits host cell NF-kappa-B activation by preventing nuclear translocation of host protein RELA/p65. Acts by mediating cysteine methylation of host proteins TAB2 and TAB3: methylation of a conserved cysteine residue of the RanBP2-type zinc finger (NZF) of TAB2 and TAB3 disrupts zinc-binding, thereby inactivating the ubiquitin chain-binding activity of TAB2 and TAB3, leading to NF-kappa-B inactivation. Also mediates cysteine methylation of host protein ZRANB3, inactivating its ability to bind ubiquitin chains.[UniProtKB:B7UI22] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli O157:H7]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen J]] | ||
| + | [[Category: Hu L]] | ||
| + | [[Category: Shao F]] | ||
| + | [[Category: Yao Q]] | ||
| + | [[Category: Zhang L]] | ||
Current revision
Crystal structure of bacterial cysteine methyltransferase effector NleE
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Categories: Escherichia coli O157:H7 | Large Structures | Chen J | Hu L | Shao F | Yao Q | Zhang L
