4w8j
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4w8j is ON HOLD Authors: Evdokimov, A.G., Moshiri, F., Sturman, E.J., Rydel, T.J., Zheng, M., Seale, J.W., Franklin, S. Description: Structure of t...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals== | |
| + | <StructureSection load='4w8j' size='340' side='right'caption='[[4w8j]], [[Resolution|resolution]] 2.78Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4w8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_kurstaki_str._HD73 Bacillus thuringiensis serovar kurstaki str. HD73]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W8J FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8j OCA], [https://pdbe.org/4w8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w8j RCSB], [https://www.ebi.ac.uk/pdbsum/4w8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w8j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CR1AC_BACTK CR1AC_BACTK] Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | For almost half a century, the structure of the full-length Bacillus thuringiensis (Bt) insecticidal protein Cry1Ac has eluded researchers, since Bt-derived crystals were first characterized in 1965. Having finally solved this structure we report intriguing details of the lattice-based interactions between the toxic core of the protein and the protoxin domains. The structure provides concrete evidence for the function of the protoxin as an enhancer of native crystal packing and stability. | ||
| - | + | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals.,Evdokimov AG, Moshiri F, Sturman EJ, Rydel TJ, Zheng M, Seale JW, Franklin S Protein Sci. 2014 Nov;23(11):1491-7. doi: 10.1002/pro.2536. Epub 2014 Sep 2. PMID:25139047<ref>PMID:25139047</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4w8j" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Delta-endotoxin|Delta-endotoxin]] | ||
| + | *[[Pesticidal crystal protein|Pesticidal crystal protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus thuringiensis serovar kurstaki str. HD73]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Evdokimov AG]] | ||
| + | [[Category: Franklin S]] | ||
| + | [[Category: Moshiri F]] | ||
| + | [[Category: Rydel TJ]] | ||
| + | [[Category: Seale JW]] | ||
| + | [[Category: Sturman EJ]] | ||
| + | [[Category: Zheng M]] | ||
Current revision
Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals
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