4mgi

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==Selective activation of Epac1 and Epac2==
==Selective activation of Epac1 and Epac2==
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<StructureSection load='4mgi' size='340' side='right' caption='[[4mgi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4mgi' size='340' side='right'caption='[[4mgi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mgi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MGI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mgi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MGI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mgz|4mgz]], [[4mh0|4mh0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mgi RCSB], [http://www.ebi.ac.uk/pdbsum/4mgi PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgi OCA], [https://pdbe.org/4mgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mgi RCSB], [https://www.ebi.ac.uk/pdbsum/4mgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgi ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Rehmann, H.]]
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[[Category: Homo sapiens]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Large Structures]]
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[[Category: Nucleotide binding]]
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[[Category: Mus musculus]]
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[[Category: Signaling protein-gtp-binding protein complex]]
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[[Category: Rehmann H]]

Current revision

Selective activation of Epac1 and Epac2

PDB ID 4mgi

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