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2mu8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum== | |
| + | <StructureSection load='2mu8' size='340' side='right'caption='[[2mu8]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MU8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mu8 OCA], [https://pdbe.org/2mu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mu8 RCSB], [https://www.ebi.ac.uk/pdbsum/2mu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mu8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MSA2_PLAF7 MSA2_PLAF7] May play a role in the merozoite attachment to the erythrocyte. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system. | ||
| - | + | Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective.,Cifuentes G, Patarroyo ME, Urquiza M, Ramirez LE, Reyes C, Rodriguez R J Med Chem. 2003 May 22;46(11):2250-3. PMID:12747797<ref>PMID:12747797</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2mu8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium falciparum]] | ||
| + | [[Category: Cifuentes G]] | ||
| + | [[Category: Patarroyo ME]] | ||
| + | [[Category: Ramirez LE]] | ||
| + | [[Category: Reyes C]] | ||
| + | [[Category: Rodriguez R]] | ||
| + | [[Category: Urquiza M]] | ||
Current revision
Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum
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